## FBXW10
- **UniProt:** Q5XX13 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40` ; **PN-node mapping:** group=mapped, ok_for_propagation_to_go, GO:1990756 (substrate-adaptor MF); subtype/type=no_mapping; projected GO:1990756 goa_status=new_to_goa.
- **Consistency:** Fully consistent. Deep research (falcon), review YAML, PN annotation and PN-node mapping all describe FBXW10 as a poorly characterized SCF F-box/WD40 substrate receptor (non-catalytic adaptor). The review's `proposed_new_terms` explicitly proposes GO:1990756, exactly matching the PN projection. No contradictions.
- **PN story / NEW pressure:** PN asserts the substrate-adaptor MF (GO:1990756) which is NOT in FBXW10's GOA (no MF adaptor/scaffold term present — confirmed in goa.tsv). GO:1990756 is real (OLS verified: "brings together a ubiquitin-like ligase and its substrate... F-box/BTB/POZ proteins") and is the canonical F-box receptor MF. Verdict: ADD GO:1990756 — already independently proposed in the review.
- **Mapping strategy:** Correct. FBXW10 is a Cul1/SCF F-box WD40 receptor; catalysis is RBX1's. GO:1990756 (receptor/adaptor) is the right category, not scaffold (GO:0160072) and not catalytic (GO:0061630). Scope ok_for_propagation. The class-level GO:0061630 is correctly held as too_broad context_only.
- **Evidence alignment:** Aligned. PN ref 15340381 = PMID:20498703 (lamin A mutants target HP1 via FBXW10), which is the review's sole experimental PMID and is marked relevance HIGH / correctness VERIFIED. Falcon adds interactome (Poirson 2017) and disease genetics; no divergence.
- **Verdict:** Consistent; PN GO:1990756 add is defensible and already mirrored in the review. No changes needed.