## FBXW2
- **UniProt:** Q9UKT8 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (high quality)
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40` ; **PN-node mapping:** group=mapped/ok_for_propagation_to_go GO:1990756 (ubiquitin-like ligase-substrate adaptor activity); class=context_only/too_broad GO:0061630; subtype/type/branch=no_mapping
- **Consistency:** Fully consistent. Deep research (falcon), review YAML, PN annotation, and PN-node mapping all converge on FBXW2 as a non-catalytic SCF(FBXW2) substrate receptor. Description, core_functions (2x GO:1990756) and the MODIFY of the catalytic GO:0004842→GO:1990756 all match the PN projected term. No contradictions.
- **PN story / NEW pressure:** PN asserts only the generic Cul1-receptor adaptor role, which the review already captures: GO:1990756 is introduced via MODIFY (transferase IEA/TAS) — it is NOT in current GOA, so projection is correctly `new_to_goa`. Term verified real via OLS. No additional NEW term needed; substrate biology (GCM1, SKP2, β-catenin, TAK1, p65, Moesin, EGFR) is well captured by description/core_functions and the GO:0031146 catabolic process. Conclusion: already captured / ADD GO:1990756 (which the review's MODIFY already proposes).
- **Mapping strategy:** Correct. Group-level GO:1990756 is neither broader nor narrower than the review's core MF; this is the recurring correct call (adaptor activity replacing catalytic transferase). Status/scope appropriate; class-level GO:0061630 correctly held as too_broad. No node change warranted.
- **Evidence alignment:** PN cites only PMID:15340381 (Cardozo & Pagano SCF review) "/ rev" — a family review, not in the review's reference list but consistent with it. Review draws substrate evidence from PMID:23651062 (GCM1/RACK1, HIGH) and PMID:35414786 (SKP2/β-catenin/TAK1, HIGH) plus falcon. Divergence is benign: PN uses the family-level review, the YAML uses gene-specific primary literature.
- **Verdict:** CONSISTENT — no edits. Validated F-box receptor; GO:1990756 ADD already handled by review MODIFY.