## FBXW5
- **UniProt:** Q969U6 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE (high quality)
- **PN placement (2 rows):** ALP: `Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component regulator` ; UPS: `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40`. **PN-node mapping:** ALP entirely no_mapping/context_only (GO:0016236 macroautophagy held too_broad); UPS group=mapped GO:1990756.
- **Consistency:** UPS branch fully consistent — review has GO:1990756 as a NEW annotation (IDA, PMID:21725316) plus GO:0019005, GO:0080008 (CRL4/DCX), GO:0031146, centrosome-duplication and cilium-assembly roles. **Gap:** the PN ALP row (FBXW5 degrades SEC23B to restrain COPII-driven autophagosome formation; ULK1 phosphorylates SEC23B) is NOT represented anywhere in the review — no SEC23B substrate, no autophagy term, and the deep research (falcon) does not mention SEC23B/autophagy. The PN ALP node citing the eLife "ULK1-FBXW5-SEC23B nexus controls autophagy" paper is a substrate/process the review omits.
- **PN story / NEW pressure:** PN ALP asserts an autophagy-regulatory role absent from GO and from the review. The PN node itself declines to project a GO term (no_mapping; macroautophagy too_broad), so there is no over-reach at the node. But the SEC23B-autophagy axis is a genuine literature finding the review should at least note. Defensible candidate term if substantiated: GO:0010506 regulation of autophagy or GO:1903146 regulation of autophagy of mitochondrion — but the review has not assessed the eLife paper, so this is "candidate, needs source verification," not a confirmed ADD. UPS side: GO:1990756 verified real, correctly new_to_goa, already present in review.
- **Mapping strategy:** Both nodes correct. UPS group GO:1990756 matches review MF (not broader/narrower). ALP no_mapping is the right conservative call given the multi-member container; do not project macroautophagy (TRAPP-like overpropagation, per rationale).
- **Evidence alignment:** UPS PN cites PMID:15340381 (family review); review uses gene-specific PMID:21725316 (SASS6/PLK4, HIGH), PMID:18381890 (TSC2/CRL4, HIGH), PMID:34368969 (kinesin-13/cilia, HIGH). ALP PN cites an eLife SEC23B paper with NO overlap in the review's references — the most salient divergence.
- **Verdict:** MOSTLY CONSISTENT; one substrate gap. **Recommended edits:** [YAML] Note the PN ALP SEC23B/autophagy axis in FBXW5 notes/description and assess the eLife "ULK1-FBXW5-SEC23B nexus" paper; if it supports a direct SCF(FBXW5)→SEC23B degradation event, consider adding it as a substrate (and a regulation-of-autophagy non-core process) — verify the PMID first. [REF] add the eLife SEC23B reference.