## FBXW9
- **UniProt:** Q5XUX1 · **batch:** proteostasis-batch-2026-06-13 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40` ; **PN-node mapping:** group=mapped/ok_for_propagation_to_go GO:1990756; class=context_only/too_broad GO:0061630; subtype/type/branch=no_mapping
- **Consistency:** Consistent. Deep research (falcon), review YAML, PN annotation, and node mapping all treat FBXW9 as an SCF/CRL1 substrate adaptor whose specific substrate(s) are NOT experimentally defined (TP53 is UbiBrowser-predicted only). The review is appropriately cautious: SCF membership ACCEPT, but GO:0031146 catabolic process is KEEP_AS_NON_CORE because no substrate is biochemically validated. No contradictions.
- **PN story / NEW pressure:** PN asserts the generic Cul1-receptor adaptor role. GOA currently lacks GO:1990756, so the projected term is correctly `new_to_goa`; the review proposes it under proposed_new_terms (GO:1990756, verified real via OLS). This is the flagged "member with NO validated substrate" case — adaptor activity is defensible from SKP1 binding (co-IP) + CUL1 AP-MS even without a known substrate. Conclusion: ADD GO:1990756 (already proposed by review); do not add any process/substrate term.
- **Mapping strategy:** Correct and conservative. Group-level GO:1990756 matches the review's proposed MF; not broader/narrower. Class-level GO:0061630 correctly too_broad. No node change.
- **Evidence alignment:** PN cites PMID:15340381 ("/ rev", SCF family review). Review anchors on PMID:15520277 (F-box nomenclature), PMID:19159283 (array MAPPIT SKP1 + co-IP), and falcon (CUL1 AP-MS). Different family-review citations but same adaptor conclusion; no conflict.
- **Verdict:** CONSISTENT — no edits. Poorly-characterized but bona fide F-box receptor (no validated substrate); GO:1990756 ADD already proposed.