## FKBP5
- **UniProt:** Q13451 (FKBP51) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `Cytonuclear|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain`; `Cytonuclear|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type`; `ALP|Autophagophore initiation|Class 3 PI3K complex 1|Modulator of BECN1 availability` ; **PN-node mapping:** mapped → GO:0051879 (Hsp90 binding, more_specific_than_existing_goa), GO:0003755 (PPIase, already_in_goa_exact); ALP node = context_only/too_broad_to_propagate (projects nothing)
- **Consistency:** Good on the chaperone/enzyme core. Review, notes and PN agree: active FKBP PPIase (FK506/rapamycin-inhibited) + HSP90 co-chaperone in steroid-receptor heterocomplexes (negative regulator, FKBP4 antagonist) + AKT1-PHLPP1 scaffold (neg reg PI3K/AKT, GO:0051898 IDA). Core MFs GO:0003755, GO:0031072, GO:0030674 — catalytic vs scaffold both captured. One gap: PN row 3 documents an autophagy-enhancing/BECN1 role that has NO counterpart in the review (autophagy appears only as a reference title).
- **PN story / NEW pressure:** Two MF projections (GO:0003755, GO:0051879) are already in the review (GO:0051879 present ×14) → **already captured**. The autophagy/BECN1 story (FKBP5 enhances autophagy via BECN1) is real PN content but its node is deliberately context_only / too_broad_to_propagate (GO:0035032 PI3K-III complex, GO:0016236 macroautophagy) → PN projects no GO term, matching the TRAPP/overpropagation precedent. So no NEW GO term is asserted; over-reach correctly avoided.
- **Mapping strategy:** Correct. Modulator-of-BECN1 node withheld from CC/BP propagation (regulator, not complex component); HSP-binding projection uses the narrower GO:0051879 (child of GO:0031072, OLS-verified) consistent with the review. No mapping change.
- **Evidence alignment:** PN row 3 cites "FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action" (tandfonline); this PMID is absent from the review. Review PI3K/AKT evidence (PMID:28147277, PMID:28363942) is FKBP5-specific and not in PN. Partial divergence on the autophagy paper.
- **Verdict:** Consistent on core; PN's autophagy role is documented but intentionally non-propagating, so no required edit. **Recommended edits:** none required; optionally note the FKBP5-autophagy/BECN1 paper in notes/references for completeness [REF]. Do not propagate GO:0035032/GO:0016236 (regulator, too broad) [MAP].