## FKBP8
- **UniProt:** Q14318 · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** 3 rows — (1) `Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing`; (2) `Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type`; (3) `Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy`. **PN-node mapping:** HSP90-cochaperone type=mapped→**GO:0051879 Hsp90 protein binding** (more_specific_than_existing_goa); PPIase group/type=mapped→**GO:0003755 PPIase activity** (already_in_goa_exact); Mitophagy type=mapped→**GO:0000423 mitophagy** (supported_by_goa_regulation); subtype/class/group/branch=no_mapping.
- **Consistency:** Notes, review YAML, and all three PN mappings are mutually consistent. The review captures the full dual-role membrane-FKBP picture: conditional Ca2+/CaM-activated PPIase (GO:0003755, ACCEPT), HSP90 co-chaperone (multiple protein-binding rows MODIFY→GO:0051879), and mitophagy receptor (GO:1901524 ACCEPT x2). No contradiction.
- **PN story / NEW pressure:** All three PN molecular roles are already in GOA/review. GO:0051879 (OLS-verified) is correctly "more_specific" — the review independently proposes it via MODIFY of HSP90 protein-binding rows. GO:0003755 is already_in_goa_exact (review ACCEPT, IEA). Mitophagy: PN maps GO:0000423 (mitophagy, verified real) but the review and GOA carry **GO:1901524 regulation of mitophagy** (IDA x2, PMID:28381481/31908024), not GO:0000423 itself — PN flags this honestly as supported_by_goa_regulation (FKBP8 is a receptor that *regulates*, rather than *is*, mitophagy). Nothing to ADD; all captured.
- **Mapping strategy:** Three leaf mappings, all defensible and gene-appropriate; ancestors correctly no_mapping (TOMM20/HSPA8-style umbrella restraint). One nuance: the Mitophagy-receptor leaf projects GO:0000423 (the process), whereas FKBP8's experimental evidence is for the *regulation* term GO:1901524. supported_by_goa_regulation captures this, but if the projection is meant to land an annotation, GO:1901524 is the better-supported target.
- **Evidence alignment:** PN row-3 titles ("FKBP8 recruits LC3A to mediate Parkin-independent mitophagy" = PMID:28381481; "Selective Autophagy: ATG8…LIR…Cargo Receptors") overlap the review's mitophagy anchors (PMID:28381481 cited; PMID:31908024 added). Strong overlap on mitophagy; PN does not surface the HSP90/dynein-relay (PMID:29916806) or CaM-activation (PMID:20707607) evidence the review adds — enrichment, not conflict.
- **Verdict:** Consistent; all PN molecular roles captured; only nuance is mitophagy process (GO:0000423) vs regulation (GO:1901524) granularity. **Recommended edits:** [MAP] optionally retarget the Mitophagy-receptor leaf projection from GO:0000423 to GO:1901524 regulation of mitophagy to match FKBP8's experimental (IDA) evidence and the review.