## GBA1
- **UniProt:** P04062 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP → Lysosomal catabolism → Lysosomal lipid catabolism → Lysosomal sphingomyelin/ceramide metabolism → Lysosomal ceramidase` AND `ALP → Autophagic lysosome reformation → Specific function in autophagic lysosome reformation unknown` (2 rows)
- **PN-node mapping:** ceramidase subtype/type = `no_mapping` (mixed ASAH1/GALC/GBA1 bucket; no safe shared ceramidase term); lipid-catabolism group = `context_only` → GO:0016042; catabolism class = `no_mapping`; ALR class = `context_only`/`too_broad` → GO:0007040 lysosome organization; ALR group ("function unknown") = `no_mapping`; branch `no_mapping`.
- **Consistency:** Excellent — the best-aligned of the set. Deep-research, review, PN, and mapping converge: core function is lysosomal acid glucosylceramidase (GO:0004348; LIMP-2/SCARB2-trafficked), and the ALR/Parkinson axis is a genuine but downstream/mechanism-unknown consequence of GCase loss. The review's handling (GO:0007040 lysosome organization; regulation of macroautophagy; "current GO lacks an autophagic lysosome reformation term") mirrors the PN node's `context_only`→GO:0007040 + "function unknown"→`no_mapping` exactly. No contradictions.
- **PN story / NEW pressure:** The PN's ALR placement asserts a role not captured by an exact GO term — and the review correctly recognizes this. OLS confirms there is NO existing GO term "autophagic lysosome reformation" (only GO:0061739 = "protein lipidation involved in autophagosome assembly", unrelated). The review already mints the right response: `proposed_new_terms` includes "autophagic lysosome reformation" (parent GO:0007040) — **candidate, correctly unverified/new** — plus "lysosomal glucosylceramide catabolic process" (parent GO:0006680). No fabricated existing term used. **Already captured (proposed_new_terms + suggested_questions); no further ADD warranted.**
- **Mapping strategy:** No change. Including GBA1 does not alter the node: the ALR group is rightly `no_mapping` ("function unknown"), the class rightly `context_only`→GO:0007040 (broader than GBA1's enzymatic core), and the ceramidase bucket rightly `no_mapping` (GBA1 is a glucosylceramidase, not a ceramidase — the PN's mixed ASAH1/GALC/GBA1 grouping is appropriately not propagated). PN-projected GO:0007040 is broader than the review's enzyme-level core, so non-propagation is the right call (cf. rejected broader projections).
- **Evidence alignment:** Strong overlap. PN cites the ALR paper (Magalhaes et al., HMG 2016) = **PMID:27378698 (verified via PubMed, DOI 10.1093/hmg/ddw185)**, and the review cites the SAME PMID:27378698 for ALR (in core_functions, the GO:0007040 annotation, and the proposed ALR term). PN's other refs (Schröder lysosome proteome; hLGDB) are localization/database context not needed by the review.
- **Verdict:** Fully consistent; exemplary handling of a "GO-gap" PN node (proposed NEW term instead of forcing an existing one), with matching primary evidence. **Recommended edits:** none.