## GET1
- **UniProt:** O00258 (WRB) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|GET pathway component` ; **PN-node mapping:** group → GO:0006620 (post-translational protein targeting to ER membrane), scope=ok_for_propagation, **goa_status=more_specific_than_existing_goa**; class → GO:0015031 (protein transport); branch=no_mapping.
- **Consistency:** Deep research (notes + falcon), review YAML, and PN annotation are consistent: GET1/WRB is the ER membrane receptor-insertase subunit of the GET pathway, with CAMLG/GET2 forming the heterotetramer that accepts GET3-delivered TA proteins. Distinction "receptor/insertase (GET1) vs ATPase targeting factor (GET3)" is honored. The review correctly MARK_AS_OVER_ANNOTATED the legacy nucleus TAS (PMID:9544840), not reproduced.
- **PN story / NEW pressure:** PN asserts post-translational ER-membrane targeting/insertion of TA proteins — already captured by review's core terms GO:0071816 (TA insertion into ER membrane), GO:0045048 (protein insertion into ER membrane), GO:0043495 (protein-membrane adaptor activity, the PAN-GO MF), GO:0043529 (GET complex). No NEW GO term warranted; already captured.
- **Mapping strategy:** GET1 does not alter the GET-node mapping. **Discrepancy flag:** GET1 dossier labels GO:0006620 `more_specific_than_existing_goa` whereas the identical GET3 mapping labels it `new_to_goa` — one is wrong (GET1's GOA carries the insertion terms but not GO:0006620 specifically; both genes should share the same goa_status for the same projected term). GO:0006620 is verified-real and a defensible group term, but is a *targeting* (not insertion) term; GET1's role is the membrane receptor-insertase, so GO:0006620 is slightly off-target for GET1 specifically (better fits GET3). Acceptable as a group/pathway-level term, but narrower-fit for GET3 than GET1.
- **Evidence alignment:** Strong overlap — review's GET-pathway PMIDs (21444755, 23041287, 27226539, 32910895, 36640319, 37963916) fully support the PN targeting/insertion claim.
- **Verdict:** Consistent; well-reviewed. Flag the GO:0006620 goa_status inconsistency between GET1 (`more_specific_than_existing_goa`) and GET3 (`new_to_goa`) dossiers and that GO:0006620 (targeting) fits GET3 better than the receptor-insertase GET1.