## GET3
- **UniProt:** O43681 (ASNA1/TRC40) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|GET pathway component` ; **PN-node mapping:** group → GO:0006620 (post-translational protein targeting to ER membrane), scope=ok_for_propagation, **goa_status=new_to_goa**; class → GO:0015031 (protein transport); branch=no_mapping.
- **Consistency:** Deep research, review YAML, and PN annotation are consistent: GET3/ASNA1/TRC40 is the cytosolic homodimeric ATPase + TMD chaperone (carrier) of the GET/TRC pathway — the targeting factor, NOT the insertase (insertase = WRB/CAML). The review cleanly distinguishes the **ATPase MF (GO:0016887 ATP hydrolysis activity)** and **carrier/chaperone MF (GO:0140597 protein carrier activity)** from the GET1 receptor role, exactly as the task brief requires. Legacy arsenite/nucleolar framing correctly treated as secondary/non-core.
- **PN story / NEW pressure:** PN asserts post-translational ER targeting of TA proteins — already captured: GO:0071816 (involved_in), GO:0016887 + GO:0140597 (core MFs), GO:0043529 (GET complex), GO:0045048 (non-core parent). No NEW GO term warranted. GO:0006620 (post-translational protein targeting to ER membrane) is a defensible, verified-real term that fits GET3's targeting role well — arguably a good *added* BP for GET3, though the GET-pathway role is conventionally captured by GO:0071816 in GOA.
- **Mapping strategy:** GET3 does not change the GET-node mapping. GO:0006620 fits GET3 (the targeting ATPase) more precisely than GET1 (the receptor-insertase). The goa_status `new_to_goa` here vs `more_specific_than_existing_goa` for the identical GET1 mapping is internally inconsistent across the two same-node genes — one needs correction.
- **Evidence alignment:** High overlap — review's targeting-pathway PMIDs (17382883, 21444755, 23041287, 23610396, 25535373, 31461301, 32910895, 36640319, 37963916) fully evidence the PN targeting claim.
- **Verdict:** Consistent; exemplary review with correct ATPase-vs-chaperone MF split. GO:0006620 is an apt (verified) targeting term for GET3; flag the cross-gene goa_status inconsistency with the GET1 dossier.