## GET4
- **UniProt:** Q7L5D6 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|GET pathway component` ; **PN-node mapping:** group=mapped scope=ok_for_propagation_to_go→GO:0006620 (post-translational protein targeting to ER membrane); class `Protein transport`=mapped→GO:0015031 (protein transport); branch=no_mapping.
- **Consistency:** Strong and mutually consistent. Deep research (falcon, incorporated into notes), the review YAML, and the PN annotation all describe GET4/TRC35 as the scaffold subunit of the BAG6/BAT3 pre-targeting complex that loads tail-anchored (TA) cargo onto GET3/TRC40 for post-translational ER insertion. The PN "GET pathway component" label and its GO:0006620 mapping match the review's core BP annotation (GO:0006620 IDA, ACCEPT). No contradictions.
- **PN story / NEW pressure:** PN asserts only the canonical post-translational ER-targeting role, which the review already captures as core (GO:0006620, GO:0071816 TA-insertion, GO:0140597 carrier activity). The secondary holdase/ERAD/quality-control branch (GO:0031647, GO:0036503, GO:0006511) is in the review but not the PN story. No new GO term needed. Conclusion: **already captured** (no NEW pressure).
- **Mapping strategy:** No change needed. GO:0006620 (goa_status already_in_goa_exact) is present and ACCEPTed in the review — the projection is exact, not broader (unlike the TOMM20/HSPA8/RAB7A "too broad" precedent). The class-level GO:0015031 is correctly flagged as a broad propagation target for the ER Protein-transport class, not for GET4 specifically.
- **Evidence alignment:** PN dossier lists no reference titles, so alignment is via projected-term provenance. Review's core support (PMID:20676083 founding Bag6/TRC complex; PMID:25535373 minimal Bag6 module SGTA→TRC40; PMID:34887561 cryo-EM GET4-GET3 lid; PMID:32395830 disease IMP) all encode the same post-translational TA-targeting biology the PN node maps to. No divergence.
- **Verdict:** Fully consistent; PN already captured by the review, which is more granular (adds TA-specific GO:0071816 and the QC branch). No edits warranted.