## GIGYF1
- **UniProt:** O75420 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** RQC type=no_mapping; RQC group=mapped→GO:0006515; class/branch context_only (GO:0002181/GO:0006412 too_broad).
- **Consistency:** Strong and mutually consistent. Deep research, notes, and review agree GIGYF1 is the cytosolic adaptor/scaffold that, via its N-terminal 4EHP-binding region and GYF domain, nucleates the 4EHP-GIGYF1-DDX6-ZNF598 module repressing cap-dependent initiation and triggering co-translational mRNA decay on ribosome-paused/stalled transcripts. Review ACCEPTs GO:0045947 (negative regulation of translational initiation, IBA) and adds GO:0008190 (eIF4E binding) as NEW core MF — both directly encode the RQC-coupled repression the PN node targets. No contradictions.
- **PN story / NEW pressure:** PN asserts only GO:0006515 (RQC umbrella, new_to_goa, verified real). The review captures the same RQC-coupled repression via the more specific GO:0045947 and the NEW GO:0008190 (eIF4E binding). GIGYF1's RQC role is real (PMID:33053355 — paused-transcript accumulation in KO; ZNF598 dependence), so GO:0006515 is defensible as an umbrella but is broader than the review's specific terms. Note the review (unlike GIGYF2's) does NOT carry GO:0072344 (rescue of stalled cytosolic ribosome) for GIGYF1 — a paralog asymmetry. **Already captured** (more specifically); GO:0006515 does not over-reach but adds nothing the review lacks functionally.
- **Mapping strategy:** RQC group→GO:0006515 is acceptable as a broad umbrella over the review's GO:0045947/GO:0017148. No mapping change required. The class/branch context_only demotions (too_broad) are correct. Worth noting for paralog consistency: GIGYF2's review additionally carries GO:0072344; GIGYF1's does not — if PN treats the paralogs as one RQC module, the GIGYF1 review could parallel GIGYF2.
- **Evidence alignment:** PN dossier lists no reference titles for GIGYF1; alignment is via the projected GO:0006515. Review's core PMIDs (33053355 translation-coupled decay; 31439631 GIGYF-4EHP-DDX6 assembly) cover exactly the RQC/repression biology the PN node encodes. No divergence.
- **Verdict:** Fully consistent; PN RQC story already captured more precisely (GO:0045947 + NEW GO:0008190). GO:0006515 is a defensible umbrella, not an over-reach. **Recommended edits:** [YAML] for paralog consistency, consider whether GIGYF1 warrants GO:0072344 (rescue of stalled cytosolic ribosome) as GIGYF2's review carries it — the underlying PMID:33053355/RQC evidence is shared (curator judgment; optional).