## GIGYF2
- **UniProt:** Q6Y7W6 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** RQC type=no_mapping; RQC group=mapped→GO:0006515; class/branch context_only (GO:0002181/GO:0006412 too_broad).
- **Consistency:** Strong and mutually consistent. Deep research, notes, and review agree GIGYF2 is the principal scaffold of the 4EHP-GYF2 repressor complex: its 4EHP-binding motif tethers EIF4E2 to the cap, its GYF domain bridges ZFP36/TTP, AGO2/TNRC6, ZNF598 and DDX6, coupling translational repression to mRNA decay; a major role is RQC negative-feedback on stalled-ribosome mRNAs. Review ACCEPTs GO:0045947 (negative reg translational initiation, IDA), GO:0072344 (rescue of stalled cytosolic ribosome, IDA), GO:0000900 (translation repressor activity), GO:0060090 (adaptor), and MODIFYs protein binding→GO:0008190 (eIF4E binding). All directly encode the RQC-coupled repression the PN node targets. No contradictions.
- **PN story / NEW pressure:** PN asserts only GO:0006515 (RQC umbrella, new_to_goa, verified real). The review already captures the RQC role more specifically via GO:0072344 (IDA, PMID:32726578) plus GO:0045947. GO:0006515 is a broad umbrella over these. **Already captured** (more precisely); GO:0006515 adds no function the review lacks and does not over-reach (GIGYF2's RQC role is directly evidenced).
- **Mapping strategy:** RQC group→GO:0006515 is an acceptable umbrella over the review's GO:0072344/GO:0045947. No mapping change required. The class/branch context_only demotions (too_broad GO:0002181/GO:0006412) are correct. GIGYF2 is the better-evidenced paralog (direct IDA for GO:0072344); the GIGYF1 review lacks GO:0072344, a paralog asymmetry to flag on the GIGYF1 side rather than here.
- **Evidence alignment:** PN dossier lists no reference titles for GIGYF2; alignment is via projected GO:0006515. Review's RQC PMIDs (32726578 RQC negative feedback; 33053355 translation-coupled decay; 31439631 complex assembly; 22751931 development) all anchor the same RQC/repression biology the PN node encodes. No divergence.
- **Verdict:** Fully consistent; PN RQC story already captured more precisely (GO:0072344 + GO:0045947 + GO:0000900). GO:0006515 is a defensible umbrella, not an over-reach. No edits warranted.