## GTPBP2
- **UniProt:** Q9BX10 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue` ; **PN-node mapping:** type `Ribosomal rescue`=mapped→GO:0072344 rescue of stalled cytosolic ribosome (more_specific_than_existing_goa); group `Ribosome-associated QC`=mapped→GO:0006515 protein quality control (new_to_goa); class/branch=context_only (too broad).
- **Consistency:** Consistent. Deep research (notes), review, and PN all agree GTPBP2 is a PELO-partnered translational GTPase that rescues ribosomes stalled on deficient/non-functional tRNA (Jaberi-Elahi syndrome, neuronal). No contradictions; the review additionally flags that GTPBP2 lacks eEF1A elongation activity (negated GO:0003746) and binds GTP only weakly — all coherent with the PN "ribosomal rescue" placement.
- **PN story / NEW pressure:** The PN rescue role is NOT captured by any process term in GTPBP2's GOA — the only BP annotation is GO:0006414 translational elongation (IBA), which the review marks MARK_AS_OVER_ANNOTATED. So GTPBP2 has no correct BP term for its actual function. GO:0072344 rescue of stalled cytosolic ribosome (verified real, non-obsolete) is the defensible ADD; GO:0006515 (verified real) is a broader parent and weaker. Conclusion: **ADD GO:0072344** (the review currently leaves the rescue role only in `description`/`core_functions` text, not as a proposed term).
- **Mapping strategy:** Node mapping is sound. Type-node GO:0072344 is the right specificity (not broader, unlike the TOMM20/HSPA8 precedent); group-node GO:0006515 is appropriately the fallback parent. The projected term is narrower-or-equal to the review's own functional picture, so no over-reach.
- **Evidence alignment:** PN dossier lists no reference titles. Review/notes anchor on PMID:30108131 (GTPBP1/GTPBP2 GTPases) and UniProt; Ishimura 2014 (mouse Gtpbp2/Pelo) cited in notes but not as a YAML reference. No citation conflict; PN simply carries no PMIDs to compare.
- **Verdict:** Consistent; PN rescue story is real NEW pressure (GOA lacks a correct BP). **Recommended edits:** add GO:0072344 rescue of stalled cytosolic ribosome to `proposed_new_terms` (or as a NEW annotation) [YAML]; consider adding Ishimura 2014 Science to `references` for the PELO-rescue/neurodegeneration evidence [REF].