## GTPBP6
- **UniProt:** O43824 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** TWO rows. Row 1 `Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly` (type & group=mapped→GO:0061668 mitochondrial ribosome assembly). Row 2 `Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes` (type=mapped→GO:7770016 rescue of stalled mitochondrial ribosome [new_to_goa]; group=mapped→GO:0070126 mitochondrial translational termination [new_to_goa]). Class/branch=context_only.
- **Consistency:** Partial mismatch. The review and notes cover ONLY the biogenesis arm (row 1): GO:1902775 mitochondrial large ribosomal subunit assembly (IDA), GO:0043023 mtLSU binding (IDA), mitochondrion, GTP binding. The review `description` does mention "recycling/dissociation of mature mitochondrial ribosomes ... dual role" (PMID:34135319), which maps to PN row 2's ribosome-rescue/recycling concept — but the review carries NO process annotation for it. PN row 2's GO:7770016 (rescue of stalled mitochondrial ribosome) and GO:0070126 (mitochondrial translational termination) are therefore absent from the review. Note: PN's "39S subunit assembly" maps to GO:0061668 (mito ribosome assembly, parent) whereas the review uses the more specific GO:1902775 (mtLSU assembly) — review is appropriately narrower.
- **PN story / NEW pressure:** PN row 2 asserts a stalled-mitoribosome-rescue/termination role not in GTPBP6 GOA and not in the review's annotations. Both projected terms verified real (GO:7770016 def: "freeing the ribosome from the stalled translation complex"; GO:0070126). However the review's recycling claim is dissociation of MATURE mitoribosomes (PMID:34135319), which is ribosome recycling, not stalled-ribosome rescue/termination — so GO:7770016 (stalled) may over-reach relative to the actual evidence; mitochondrial ribosome recycling / GO:0070126 is the better-fitting concept. Conclusion: biogenesis already captured (more specifically); row-2 termination story is **over-reaches as "stalled-ribosome rescue"** but a recycling term is defensible.
- **Mapping strategy:** Row 1 fine. Row 2 changes nothing in the review and risks projecting a stalled-rescue term onto a recycling function — recommend treating GO:7770016 as context-only for GTPBP6 pending evidence that GTPBP6 acts on STALLED (not mature) mitoribosomes.
- **Evidence alignment:** PN lists no titles. Review anchors on PMID:34135319 (the single key structural paper, supports both biogenesis AND recycling), PMID:34800366 (mito proteome), PMID:9466997 (cloning). PN row 2 cites no PMID to compare.
- **Verdict:** Mostly consistent on biogenesis (already captured, review narrower); row-2 stalled-ribosome-rescue projection over-reaches vs the recycling evidence. **Recommended edits:** keep GO:7770016 as context-only / do not propagate to GTPBP6 unless stalled-ribosome evidence is found [MAP]; optionally add a mitochondrial-ribosome-recycling process annotation (anchored to PMID:34135319 dual-role) to capture row 2 accurately [YAML].