## HBS1L
- **UniProt:** Q9Y450 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue` ; **PN-node mapping:** type `Ribosomal rescue`=mapped→GO:0072344 rescue of stalled cytosolic ribosome (already_in_goa_exact); group `Ribosome-associated QC`=mapped→GO:0006515 protein quality control (new_to_goa); class/branch=context_only.
- **Consistency:** Fully consistent. Deep research, review, and PN all describe HBS1L as the GTPase subunit of the Pelota-HBS1L (Dom34-Hbs1) complex that licenses PELO/ABCE1 ribosome splitting and triggers no-go/non-stop decay. The review is rich and well-aligned (multiple IDA GO:0072344, GO:0032790 ribosome disassembly, GO:0070966 no-go decay, GO:1990533 Dom34-Hbs1 complex). The isoform-2 (HBS1LV3) SKI/exosome scaffolding role is an added reviewer dimension outside the PN frame, not a contradiction.
- **PN story / NEW pressure:** No NEW pressure. PN's rescue story (GO:0072344) is already in GOA exact and richly ACCEPTED in the review (IBA + 2×IDA + TAS). The group-level GO:0006515 is a broad parent already entailed by the specific rescue/RQC terms HBS1L carries. Conclusion: **already captured** (more specifically than the PN projection).
- **Mapping strategy:** Mapping matches precedent correctly — type-node GO:0072344 is exact and already in GOA; group-node GO:0006515 is a broader parent and should be treated as entailed/context, not separately propagated (would duplicate the more specific rescue/no-go terms). No node change driven by this gene.
- **Evidence alignment:** PN lists no reference titles. Review cites the canonical mechanistic set: PMID:21448132 (Pelota/Hbs1/ABCE1 dissociation), PMID:27863242 (cryo-EM), PMID:23667253 (non-stop decay), PMID:20947765 (Dom34:Hbs1 yeast), PMID:9872408 (original eRF3-related characterization), PMID:28204585 (short-isoform SKI/exosome). No citation conflict; PN simply carries no PMIDs.
- **Verdict:** Fully consistent; PN rescue story already captured (more specifically) — no NEW pressure. **Recommended edits:** none warranted; treat group-node GO:0006515 as context-only/entailed for HBS1L (do not add as a separate annotation) [MAP].