## KIF5B
- **UniProt:** P33176 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagosome closure maturation and lysosome fusion|Localization of the lysosome` (row 1) and `ALP|Autophagic lysosome reformation|Lysosomal tubulation` (row 2) ; **PN-node mapping:** row1 group `mapped / ok_for_propagation / GO:0032418 lysosome localization`; row2 group+class `context_only / too_broad_to_propagate / GO:0007040 lysosome organization`.
- **Consistency:** Mutually consistent. Deep research, review YAML, PN notes, and node mapping all describe a kinesin-1 heavy-chain motor recruited (Arl8/SKIP) to position lysosomes. The single projected term GO:0032418 is present in the review as IMP/KEEP_AS_NON_CORE (PMID:22172677), matching `already_in_goa_exact`. No contradictions.
- **PN story / NEW pressure:** The PN ALR/lysosomal-tubulation story (KIF5B pulling autolysosome tubules via PI(4,5)P2) goes beyond current GO, but the node itself is `context_only/too_broad` and projects nothing. Review explicitly declines to add a lysosome-organization/ALR term, noting the tubulation evidence is not KIF5B-specific enough. Conclusion: already captured (lysosome localization); ALR role over-reaches for a new term now — correctly deferred to expert question.
- **Mapping strategy:** No change. The `mapped` lysosome-localization node and the two `context_only` lysosome-organization nodes are appropriately scoped; KIF5B does not push the ALR node toward propagation (parallels TOMM20/RAB7A "broader, rejected").
- **Evidence alignment:** PN cites Cheng/Schiefermeier-type ALR reviews + the KIF5B lysosome-distribution paper; review anchors the same biology to PMID:22172677 (Arl8/SKIP) and PMID:24088571 (Arl8b/NK granules). PN's ALR review titles are not cited as PMIDs in the review, but the substantive lysosome-positioning evidence overlaps.
- **Verdict:** Consistent and well-scoped; PN ALR story noted but correctly not propagated. No edits required.