## LAMP1
- **UniProt:** P11279 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagic lysosome reformation|Regulation of autolysosome morphology` ; **PN-node mapping:** group `no_mapping`; parent class `context_only / too_broad_to_propagate / GO:0007040 lysosome organization`; branch `no_mapping`. No projected GO terms.
- **Consistency:** Consistent. PN note ("LAMP1 recruits clathrin to tubules during ALR") is acknowledged in LAMP1-notes.md, which states the cached Rong et al. ALR abstract (PMID:22885770) supports clathrin/PI(4,5)P2 as ALR components but gives no LAMP1-specific statement. Review therefore does not add an ALR annotation and treats GO:0000421/GO:0044754 (autophagosome/autolysosome) as MARK_AS_OVER_ANNOTATED / KEEP_AS_NON_CORE. No contradiction.
- **PN story / NEW pressure:** PN asserts a LAMP1 ALR-morphology role absent from GO, but the node projects nothing and the review correctly judges the evidence insufficient. The review's own NEW pressure is elsewhere: a proposed_new_term "lysosomal proton channel inhibitor activity" (parent GO:0008200) for the TMEM175 mechanism (PMID:37390818). I verified via OLS that no such GO term exists, so this is a defensible new-term candidate, not already captured; the existing GO:0008200 ion channel inhibitor activity is the best current term and is ACCEPTed. Conclusion: ALR over-reaches; TMEM175-inhibitor new term is justified (candidate).
- **Mapping strategy:** No change. `no_mapping` for the ALR-morphology container is correct (descendants mix components/regulators); the `context_only` lysosome-organization framing at the class level is right. LAMP1 does not justify upgrading the node to propagation.
- **Evidence alignment:** PN cites one ALR review ("Membrane Trafficking in Autophagy"); review's load-bearing evidence is independent (PMID:37390818 TMEM175, PMID:23632890 NK granules, PMID:22641697 TAPL). Divergence is expected: PN row is search context, not the core LAMP1 function.
- **Verdict:** Consistent; PN ALR story correctly not propagated. TMEM175 proton-channel-inhibitor proposed new term is a real GO gap. No edits required.