## LMAN1
- **UniProt:** P49257 (Protein ERGIC-53 / MR60) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE, very thorough (~80 annotations; detailed notes + Falcon).
- **PN placement:** `ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone` ; **PN-node mapping:** type "Lectin chaperone" no_mapping; group "N-glycosylation system" mapped→GO:0006487 (protein N-linked glycosylation, ok_for_propagation, new_to_goa); class/branch no_mapping.
- **Consistency:** Deep research ↔ review ↔ PN annotation are internally consistent on identity: LMAN1 is correctly an L-type lectin cargo receptor (D-mannose binding GO:0005537), NOT a glycosidase/mannosidase — exactly matching the PN "Lectin chaperone" type. Review core = D-mannose binding + ER→Golgi transport (GO:0006888) of FV/FVIII via the LMAN1-MCFD2 cargo-receptor complex (GO:0062137). No contradictions.
- **PN story / NEW pressure:** No NEW GO pressure. The lectin/cargo-receptor functions are fully captured in existing GOA. Falcon additions (cryo-EM tetramer PMID:38493152, TPO cargo PMID:39499573, KKFF motif PMID:36594468) refine but do not require new terms. Conclude: already captured.
- **Mapping strategy:** **The group projection GO:0006487 (protein N-linked glycosylation) over-reaches for LMAN1.** LMAN1 *reads* high-mannose N-glycans as a cargo receptor; it neither installs (GO:0006487 = attachment via Asn N4) nor processes/trims them. Marked `new_to_goa` — i.e. it would be a brand-new, unsupported assertion. The "N-glycosylation system" group conflates installers (OST), processors (MAN1B1/EDEM) and readers (lectins) under one biosynthesis term that only describes installation. Like the TOMM20/HSPA8/RAB7A precedents, this projected term is broader/wrong-branch relative to the review's actual function and should not propagate to LMAN1.
- **Evidence alignment:** PN dossier is mapping-only (no titles). Review evidence is extensive and PubMed-verified (PMID:12717434, 16304051, 36490287, 24498414, etc.). No shared-citation conflict; the divergence is conceptual (group GO term vs. lectin function), not bibliographic.
- **Verdict:** Review strong and PN-consistent on identity (lectin, not mannosidase). PN node correct to leave "Lectin chaperone" unmapped; the inherited group→GO:0006487 projection is an over-reach for a glycan-reader.
**Recommended edits:** [MAP] Do not propagate GO:0006487 (protein N-linked glycosylation) to LMAN1 from the "N-glycosylation system" group — LMAN1 binds/transports high-mannose glycoproteins, it does not perform N-linked glycosylation; flag the group node as over-broad (mixes installers/processors/readers).