## MAP3K20
- **UniProt:** Q9NYL2 (ZAK/MLK7/MRK) · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** type `other RQC processes`=no_mapping; group `Ribosome-associated QC`=mapped→GO:0006515 protein quality control (new_to_goa); class/branch=context_only.
- **Consistency:** Consistent. Deep research, review, and PN agree MAP3K20/ZAKalpha is the ribotoxic-stress-response kinase — the proximal sensor of ribosome collisions (binds ribosome / helix 14 of 18S rRNA, autophosphorylates) that routes signals to JNK/p38 (cell death) or GCN2 (ISR). PN deliberately places it in "other RQC processes" with type=no_mapping (sensor/signaling, not a core ubiquitination/rescue effector), which matches the review framing exactly. No contradiction.
- **PN story / NEW pressure:** Subtle. PN maps only the GROUP node GO:0006515 (protein quality control) — broad. MAP3K20 is a ribotoxic-stress SENSOR/SIGNALING kinase, not a protein-QC catabolic effector, so GO:0006515 over-attributes a QC-disposal process to it. The review's rich, accurate captures are GO:0043022 ribosome binding (IDA), GO:0070181 small ribosomal subunit rRNA binding (IDA), GO:0051403 stress-activated MAPK cascade, GO:0140469 GCN2-mediated signaling, GO:0070269 pyroptosis. There is no missing term — the ribotoxic-stress/collision-sensing role is well annotated. Conclusion: **already captured**; PN group GO:0006515 over-reaches for a sensor kinase.
- **Mapping strategy:** Correct that the type node ("other RQC processes") is no_mapping. The group-level GO:0006515 should be treated as context_only for MAP3K20 — it is a heterogeneous QC umbrella and MAP3K20's role is upstream sensing/signaling, not nascent-chain disposal. Distinguishing broad GO:0006515 from MAP3K20's specific ribosome-binding/stress-cascade terms is exactly the branch-guidance concern.
- **Evidence alignment:** PN lists no reference titles. Review anchors on PMID:32289254 (ZAKalpha sensor domains / 18S helix-14), PMID:32610081 (collisions → cell fate, p38/JNK vs GCN2), PMID:35857590 (NLRP1 inflammasome/pyroptosis), plus the classical MRK/ZAK kinase papers. No citation conflict; PN carries no PMIDs.
- **Verdict:** Consistent; ribotoxic-stress sensor role already well captured — PN group GO:0006515 over-reaches for a signaling kinase. **Recommended edits:** treat group-node GO:0006515 as context-only for MAP3K20 (do not propagate the protein-QC catabolic process to a sensor/signaling kinase) [MAP]; no YAML changes needed.