## NAA10
- **UniProt:** P41227 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** two rows — `Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component` (TR) and `Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|mTORC1 signal integration` (ALP). **PN-node mapping:** NatA/NatE subtype→GO:0031415 NatA complex (mapped, CC); Nt-acetylation type→GO:0006474 N-terminal protein amino acid acetylation (mapped, BP); ALP nodes all no_mapping/context_only.
- **Consistency:** Excellent agreement for the core. Review (catalytic NatA subunit), notes, and PN all agree NAA10 is the **catalytic** NatA subunit: NatA complex (GO:0031415, IDA/IPI accepted) and N-terminal acetyltransferase activity (GO:0004596/GO:1990189/GO:0008999, EXP/IDA accepted). The ALP/mTORC1-via-TSC2 role is a documented moonlighting function; the PN correctly maps it to nothing (no_mapping), and the review treats the analogous moonlighting (Hsp70 acetylation GO:1904592, sister-chromatid GO:2000719) as KEEP_AS_NON_CORE. No contradictions.
- **PN story / NEW pressure:** The Nt-acetylation BP GO:0006474 is flagged `more_specific_than_existing_goa` (new_to_goa for that exact term) but is the parent of NAA10's existing specific EXP terms (GO:1990189 Ser, GO:0008999 Ala) — so it is **already captured** at finer granularity; adding the generic parent adds nothing. No genuine NEW pressure. The TSC2/mTOR/autophagy story (PN ALP row) is real but moonlighting and correctly left unmapped; not a defensible universal GO assertion.
- **Mapping strategy:** No node change needed. GO:0031415 NatA complex is exact for NAA10. GO:0006474 projection is a broader parent of the gene's specific MF terms — acceptable as a node-level label but redundant at gene level. NAA10 is the right anchor (catalytic subunit) for the NatA node.
- **Evidence alignment:** PN ALP row cites the ARD1/TSC2/mTOR Science Signaling paper (Kim et al.); the review does not cite that specific paper but captures equivalent moonlighting via PMID:27708256 (Hsp70) and PMID:27422821 (cohesion). PN TR row carries no titles. Core NatA evidence (PMID:15496142, 19480662, 25489052, 29754825) is robust and VERIFIED. Note: review flags PMID:25732826 as WRONG_IDENTIFIER (resolves to a Naa60 paper) — a citation issue already adjudicated, unrelated to PN.
- **Verdict:** Consistent; catalytic-subunit role correct; moonlighting correctly non-core/unmapped. No edits. (The PN GO:0006474 projection is redundant given NAA10's specific Ser/Ala EXP terms.)