## NAA15
- **UniProt:** Q9BXJ9 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component` (TR only). **PN-node mapping:** subtype→GO:0031415 NatA complex (mapped, CC); type→GO:0006474 N-terminal protein amino acid acetylation (mapped, BP); group no_mapping; class/branch context_only.
- **Consistency:** Agreement on identity and complex: review (notes, deep-research) and PN agree NAA15 is the **auxiliary, non-catalytic** NatA subunit — NatA complex (GO:0031415, IBA/IPI/IDA accepted) and ribosome anchoring (GO:0043022 IDA accepted) and activator activity (GO:0010698 IBA accepted). The review is careful that NAA15 is NOT catalytic (it MARK_AS_OVER_ANNOTATED'd the bare GO:0016407 acetyltransferase activity contributes_to). One tension: the PN projects the **BP** GO:0006474 (the acetylation *process*) onto NAA15; the review captures the auxiliary contribution via the activator MF (GO:0010698) and ribosome binding, not via a process term — but NAA15 "involved_in N-terminal acetylation" is defensible as process participation, so this is a soft, not hard, divergence.
- **PN story / NEW pressure:** No NEW pressure. NatA membership and the activator/ribosome-anchoring functions are fully captured. The PN GO:0006474 process projection is **broader/less specific** than the review's precise non-catalytic MF framing and risks implying catalytic involvement.
- **Mapping strategy:** GO:0031415 NatA complex (CC) projection is exact and appropriate for NAA15 — this is the right shared term for both NAA10 and NAA15 at the complex-component subtype. The BP GO:0006474 node mapping is fine at the *type* node generically, but at gene level for an auxiliary subunit it over-reaches toward catalysis; the activator MF is the more honest gene-level term.
- **Evidence alignment:** PN row carries no reference titles. Review anchors on PMID:15496142, 19480662, 25489052 (VERIFIED, NatA structure/complex) plus the moonlighting Ku70/Ku80 osteocalcin role (PMID:12145306, kept non-core). No conflict.
- **Verdict:** Consistent on complex/auxiliary identity; non-catalytic role correctly emphasized. No edits required. Caveat: prefer the activator MF (GO:0010698) over the catalytic-flavored BP GO:0006474 when describing NAA15's contribution.