## NAA30
- **UniProt:** Q147X3 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component` ; **PN-node mapping:** subtype mapped→GO:0031417 NatC complex (ok_for_propagation); type mapped→GO:0006474 N-terminal protein amino acid acetylation (ok_for_propagation, new_to_goa)
- **Consistency:** Strong. Deep-research notes, review YAML and PN dossier all agree NAA30 is the **catalytic** subunit of NatC (=NAA30+NAA35+NAA38, hMak3/hMak10/hMak31), co-translational Nt-acetylation of retained Met before bulky/hydrophobic residues, ribosome-associated. PN-node mapping (NatC complex CC; Nt-acetylation BP) matches the review's MF/CC content. No contradictions.
- **PN story / NEW pressure:** PN projects the **BP** GO:0006474 (N-terminal protein amino acid acetylation) — verified real and non-obsolete via OLS; confirmed absent from NAA30 GOA (grep). The review captures the **MF** (GO:0004596, GO:0120518) and **CC** (GO:0031417) but has no BP for the acetylation *process*. GO:0006474 is the BP aspect, not a parent of the MF terms, so it is genuinely complementary. Conclusion: **ADD** GO:0006474 (involved_in) is defensible and would round out MF/BP/CC; not an over-reach for the catalytic subunit.
- **Mapping strategy:** Sound for the catalytic subunit. Subtype→NatC complex (exact CC) and type→Nt-acetylation BP are both appropriate and not too broad (NAA30 directly performs the catalysis). No change to node mapping warranted.
- **Evidence alignment:** Concordant. PN row carries no reference titles; review/notes anchor to PMID:19398576 (NatC characterization, hMak3 catalytic; IDA GO:0004596/GO:0031417) and PMID:37891180 (Nt-acetylation shields from degradation). Both VERIFIED in the YAML reference_review. No divergence.
- **Verdict:** Consistent and high-quality. Optional ADD of BP GO:0006474 to the review to mirror the PN projection. **Recommended edits:** Add existing/new BP annotation GO:0006474 (N-terminal protein amino acid acetylation, involved_in) to NAA30 review [YAML].
- **2026-06-18 follow-up:** Implemented the YAML edit: added GO:0006474 N-terminal protein amino acid acetylation as a NEW BP recommendation and added it to the catalytic NatC core function.