## NAA38
- **UniProt:** Q9BRA0 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component` ; **PN-node mapping:** subtype mapped→GO:0031417 NatC complex (ok_for_propagation); type mapped→GO:0006474 N-terminal protein amino acid acetylation (ok_for_propagation, new_to_goa)
- **Consistency:** Strong. All sources agree NAA38 (LSMD1/MAK31) is the small Sm-like (LSm-fold) **non-catalytic auxiliary** subunit of NatC; correctly no catalytic MF. PN-node mapping matches.
- **PN story / NEW pressure:** PN projects BP GO:0006474 (verified real; confirmed absent from NAA38 GOA). As with NAA35, an `involved_in` BP for the auxiliary subunit of the acetylating complex is defensible and complements the CC-only core. Conclusion: **ADD GO:0006474 (involved_in)** reasonable; catalytic MF must NOT be added. Separately, the review correctly flags the family-level GO:0003723 (RNA binding, from the Sm-like signature) as MARK_AS_OVER_ANNOTATED — consistent with the PN treatment as a NatC subunit, not an RNA-binding protein. Not an over-reach.
- **Mapping strategy:** Correct. Subtype→NatC complex exact CC; BP at type level. No node-mapping change warranted.
- **Evidence alignment:** Concordant. Review/notes anchor to PMID:19398576 (NatC; hMak31; IDA GO:0031417, IMP GO:0043066) and PMID:37891180. PN row carries no titles. No divergence.
- **Verdict:** Consistent, high-quality. Same minor notes-vs-YAML mismatch as NAA35: notes say HT protein-binding PMID:25416956/PMID:32814053 should be MARK_AS_OVER_ANNOTATED, YAML uses KEEP_AS_NON_CORE. **Recommended edits:** Add BP GO:0006474 (involved_in, auxiliary subunit) to NAA38 review [YAML]; optionally reconcile PMID:25416956 / PMID:32814053 protein-binding actions with notes [YAML].
- **2026-06-18 follow-up:** Implemented the high-confidence YAML edit: added GO:0006474 N-terminal protein amino acid acetylation as a NEW BP recommendation and core process for the NatC auxiliary subunit, using IC to reflect inference from NatC complex membership rather than direct catalytic activity. The optional protein-binding action-style reconciliation remains separate.