## NBR1
- **UniProt:** Q14596 · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (~1021 lines)
- **PN placement:** ALP `Autophagy substrate selection|Selective autophagy receptor|{Pexophagy,Aggrephagy,Midbody autophagy}` + UPS `Ubiquitin and UBL binding|trafficking|selective autophagy|UBA` ; **PN-node mapping:** Pexophagy→GO:0000425, Aggrephagy→GO:0035973, Midbody→GO:0160247 cargo adaptor; ancestors no_mapping/context_only.
- **Consistency:** Highly consistent. Deep research (Rasmussen 2022 JCB; Vargas 2023 NRMCB) confirms archetypal SLR — UBA polyUb binding, LIR, AH+UBA peroxisome targeting, p62-body recruitment. Review and PN both center the cargo-adaptor/receptor MF. Notable nuance both capture: NBR1/p62 can be dispensable for aggrephagy in some cell types (Trapannone 2023) — receptor redundancy, not a contradiction. Review REMOVEs GO:0005758 mito intermembrane space (no support; only colocalizes with mitochondria during mitophagy) — well-justified.
- **PN story / NEW pressure:** Review proactively adds the same receptor MF the PN elevates: GO:0160247 autophagy cargo adaptor activity as **NEW** (action: NEW), plus GO:0035973 aggrephagy NEW and GO:0032480 negative regulation of type I IFN production NEW. Review also proposes a child term `pexophagy receptor activity` under GO:0160247. So PN's GO:0000425 pexophagy (process) is captured by review only at the MF/locational level, not as the BP term GO:0000425 — a minor gap (review has peroxisomal-membrane locations + proposed pexophagy-receptor MF but no GO:0000425 BP annotation).
- **Mapping strategy:** Mappings sound. KEY PATTERN fully realized: review independently elevated GO:0160247 over bare protein binding (~12 IPI kept non-core). PN GO:0160247 (more_specific_than_existing_goa) matches the review's NEW exactly.
- **Evidence alignment:** Strong ALP-branch overlap (Kirkin 2009 "A Role for NBR1...", TRAF6/midbody, CEP55, peroxisome receptor). Review adds Rasmussen 2022 reconstitution not in PN refs.
- **Verdict:** CONSISTENT and convergent — review already adds GO:0160247 NEW. Minor: consider adding GO:0000425 pexophagy BP to match PN projection. **Recommended edits:** consider [YAML] add existing/new GO:0000425 pexophagy (involved_in) to NBR1 review to mirror PN projection and SQSTM1 co-receptor evidence.