## NEMF
- **UniProt:** O60524 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** type `other RQC processes`→no_mapping; group `Ribosome-associated QC`→GO:0006515 protein quality control for misfolded or incompletely synthesized proteins (ok_for_propagation, new_to_goa)
- **Consistency:** Strong. Deep-research notes, review YAML and PN dossier all agree NEMF is the mammalian Rqc2/RQC2 ortholog: core RQC subunit that senses stalled 60S via the nascent-chain-conjugated P-site tRNA, recruits LTN1, and catalyzes **CAT/Ala tailing** (GO:0140708) of stalled nascent chains. PN placement under Ribosome-associated QC matches.
- **PN story / NEW pressure:** PN projects GO:0006515 (protein quality control for misfolded or incompletely synthesized proteins) at the group level. **Verified real and non-obsolete via OLS.** Critically, OLS ancestor check shows the review's RQC terms GO:1990116 (ribosome-associated ubiquitin-dependent protein catabolic process) and GO:0072344 (rescue of stalled cytosolic ribosome) do **NOT** have GO:0006515 as an ancestor (they sit in the ubiquitin-catabolic branch). So GO:0006515 is a genuinely distinct, complementary QC-aspect term not currently captured. Conclusion: **ADD GO:0006515 (involved_in)** is defensible for NEMF and not redundant with existing annotations; the group projection is well justified ("GO lacks a dedicated RQC term" rationale is accurate — RQC is captured only via the catabolic/rescue children).
- **Mapping strategy:** Reasonable. type→no_mapping (correct: "other RQC processes" is a heterogeneous bucket); group→GO:0006515 is the safe broader QC target. Not too broad to project for a bona fide RQC factor. No change warranted.
- **Evidence alignment:** Concordant and rich. Review anchors CAT tailing to PMID:33406423 and PMID:33909987 (both VERIFIED), 60S sensing/LTN1 recruitment to PMID:25578875, RQC review PMID:35452614. PN row carries no titles; review is broader. No divergence.
- **Verdict:** Consistent, high-quality; PN projection of GO:0006515 is a defensible ADD (distinct QC aspect, verified absent from GOA and not an ancestor of existing terms). **Recommended edits:** Add GO:0006515 (protein quality control for misfolded or incompletely synthesized proteins, involved_in) to NEMF review to mirror the PN projection [YAML].