## NPLOC4
- **UniProt:** Q8TAT6 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** 6 rows across ER, TR, UPS branches — ERAD (`ER proteostasis|...|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories`), RQC (`Translation|...|Ribosome-associated QC|Ubiquitin recognition`), and four UPS DUB/MPN-domain rows. **PN-node mapping:** ERAD group→GO:0036503 ERAD pathway (exact, already_in_goa); RQC group→GO:0006515 (ok_for_propagation, new_to_goa); VCP-associated subtype→GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex (ok_for_propagation, already_in_goa); all DUB/MPN nodes→context_only/no_mapping (correctly suppressed).
- **Consistency:** Strong on the core, with one correctly-handled caveat. Review/notes and PN agree NPLOC4=NPL4, the ubiquitin-binding cofactor that with UFD1 forms the UFD1-NPL4 heterodimer / VCP-NPL4-UFD1 segregase, central to ERAD retrotranslocation and many p97 processes. The UPS DUB/MPN rows reflect NPLOC4's **non-catalytic MPN-like (pseudo-DUB)** domain; the PN correctly did NOT propagate DUB activity (GO:0101005) from these — consistent with the review, which asserts ubiquitin binding (GO:0043130) and ATPase binding (GO:0051117), NOT deubiquitinase activity. No contradiction.
- **PN story / NEW pressure:** Two relevant projections. (1) GO:0034098 and GO:0036503 are confirmed **already in GOA** (grep) and accepted in the review — already captured, no NEW pressure. (2) GO:0006515 (RQC group) is verified real, absent from NPLOC4 GOA, and NOT an ancestor of the review's existing RQC terms (GO:1990116/GO:0072344, NAS, kept non-core). So GO:0006515 would be an ADD; however the review treats p97-RQC as **one of many** p97 processes (non-core), so adding it as non-core is defensible but low priority. Conclusion: core p97/ERAD story fully captured; GO:0006515 a permissible non-core ADD, not over-reach.
- **Mapping strategy:** Well-judged across all 6 rows. Suppressing DUB propagation from the MPN/UBXL nodes (NPLOC4 is a pseudo-DUB) avoids a false catalytic claim; VCP-NPL4-UFD1 complex and ERAD are the safe targets. No node-mapping change warranted.
- **Evidence alignment:** Concordant. PN rows 4-5 cite PMID:12370088 and PMID:28451587; review anchors complex/ERAD/RIG-I to PMID:11574150, PMID:25660456, PMID:26471729, PMID:28819009, RQC to PMID:35452614. Review independently caught PMID:39329031 as WRONG_IDENTIFIER (Morocco ID clinical study mis-attached by ComplexPortal) — a real citation defect the PN does not surface.
- **Verdict:** Consistent, high-quality; core captured, DUB correctly suppressed, one ComplexPortal mis-citation already flagged. **Recommended edits:** Optionally add GO:0006515 (involved_in, non-core) to mirror the RQC-group projection [YAML]; PMID:39329031 already flagged WRONG_IDENTIFIER on GO:0034098/GO:0043161/GO:1904949 — replace with a correct p97 complex reference [REF].