## NUFIP1
- **UniProt:** Q9UHK0 · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (thorough, dual-function)
- **PN placement:** 1 row — `ALP|Autophagy substrate selection|Selective autophagy receptor|Ribophagy`. **PN-node mapping:** Ribophagy type → mapped/ok GO:0034517 ribophagy (new_to_goa); ancestors (group/class/branch) = no_mapping.
- **Consistency:** Strongly consistent. PN (ribophagy receptor binding ATG8/ubiquitinated cargo), review, notes and references all agree: NUFIP1's headline cytoplasmic function is the starvation/mTORC1-induced ribophagy receptor that binds ribosomes (with ZNHIT3) and LC3B via a LIR motif (PMID:29700228, Wyant et al. Science 2018). The review also fully covers the second, nuclear box C/D snoRNP-assembly function (which PN does not address — PN is single-row, ALP-only). No contradictions; PN simply scopes only the autophagy arm.
- **PN story / NEW pressure:** Strong, defensible ADD pressure: ribophagy is genuinely absent from GOA (confirmed — NUFIP1 GOA has no ribophagy/autophagy term). GO:0034517 ribophagy is verified real. The review ALREADY adds this as a core function (GO:0034517 ribophagy involved_in + GO:0160247 autophagy cargo adaptor activity as the MF, both supported by PMID:29700228) — fully matching the PN projection. The review additionally proposes a NEW bespoke "ribophagy receptor activity" term; per the established precedent (BNIP3L/CALCOCO1) this over-reaches — the existing GO:0160247 autophagy cargo adaptor activity already captures the ribosome-LC3B bridging MF and should be used instead of minting a new term.
- **Mapping strategy:** No node change needed. Ribophagy projection (GO:0034517) is correct, specific, and new_to_goa. Cargo-adaptor MF (GO:0160247) over bare protein binding is the prescribed receptor pattern and the review already uses it. The PN node need not also project the MF — the review covers it.
- **Evidence alignment:** Strong overlap on the autophagy arm. PN cites the LIR/cargo-receptor review and the Wyant ribophagy paper (= PMID:29700228, review HIGH, PubMed-verified). Review refs additionally span the snoRNP-assembly (PMID:17636026) and FMRP/transcription (PMID:10556305, 15107825) functions that PN omits.
- **Verdict:** Consistent; ribophagy ADD already implemented in review; only the proposed bespoke MF term over-reaches. **Recommended edits:** [YAML] drop the `proposed_new_terms` "ribophagy receptor activity" entry — the existing GO:0034517 ribophagy (BP) + GO:0160247 autophagy cargo adaptor activity (MF), both already in the review's core_functions, fully capture the role (mirrors the BNIP3L/CALCOCO1 "use existing terms, don't mint new" precedent).
- **2026-06-18 follow-up:** Implemented the YAML cleanup: added explicit NEW recommendations for GO:0034517 ribophagy and GO:0160247 autophagy cargo adaptor activity, and removed the redundant bespoke ribophagy-receptor NTR block.