## OPTN
- **UniProt:** Q96CV9 (optineurin) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (~1708 lines)
- **PN placement:** ALP `Autophagy substrate selection|Selective autophagy receptor|{Mitophagy,Xenophagy,Aggrephagy}` + UPS `Ubiquitin and UBL binding|trafficking|selective autophagy|UBAN, NEMO-type ZnF` ; **PN-node mapping:** Mitophagy→GO:0000423 (entailed_by_goa_closure), Xenophagy→GO:0098792 (supported_by_goa_regulation), Aggrephagy→GO:0035973 (new_to_goa); ancestors no_mapping/context_only.
- **Consistency:** Strong on mitophagy + xenophagy. Deep research/notes (Wild 2011 PMID:21617041 Salmonella/TBK1-S177; Wong&Holzbaur 2014 PMID:25294927 Parkin mitophagy, UBAN E478G) match review. Review uses **more specific terms than PN**: GO:0061734 type 2 mitophagy (IMP; verified child of GO:0000423) and GO:1904417 positive regulation of xenophagy (IMP) — both already in GOA. One divergence: PN row 3 projects GO:0035973 aggrephagy as new_to_goa, but neither the review nor the notes assert OPTN aggrephagy — the notes/refs document mitophagy and xenophagy, not aggregate clearance.
- **PN story / NEW pressure:** PN's mitophagy/xenophagy are already captured (more precisely) — not new pressure. The only genuinely NEW PN assertion is aggrephagy (GO:0035973). This **over-reaches** on current OPTN evidence: aggrephagy appears to be carried over from the generic "Selective autophagy receptor" group notes (shared verbatim across receptors) rather than OPTN-specific data. Candidate at best; do not ADD without OPTN-specific aggrephagy evidence.
- **Mapping strategy:** Mappings reasonable but the aggrephagy leaf membership for OPTN looks like a group-note artifact. TOMM20/HSPA8/RAB7A precedent: review's GO:0061734/GO:1904417 (narrower) are preferred over PN's broader GO:0000423/GO:0098792 — review is already better. KEY PATTERN: review keeps ~40 IPI protein binding non-core and uses GO:0030674 adaptor as core MF (not GO:0160247, but functionally equivalent elevation).
- **Evidence alignment:** Excellent overlap on the two shared papers (21617041, 25294927). No paper supports the PN aggrephagy leaf.
- **Verdict:** CONSISTENT on mitophagy/xenophagy (review more specific); PN aggrephagy (GO:0035973) over-reaches / likely group-note carryover. **Recommended edits:** [MAP] reconsider OPTN membership in the Aggrephagy receptor leaf (GO:0035973 new_to_goa) — unsupported by OPTN-specific evidence; demote to context or drop.