## P3H2
- **UniProt:** Q8IVL5 (LEPREL1) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis | Maturation and folding of specific substrates | ER collagen processing and folding` ; **PN-node mapping:** group=mapped, scope=ok_for_propagation_to_go, GO=GO:0032964 collagen biosynthetic process (class/branch = no_mapping). Projection goa_status=more_specific_than_existing_goa.
- **Consistency:** Fully consistent. Deep research (notes + falcon), review YAML, PN annotation, and node mapping all describe an ER-lumenal 2-OG/Fe(II) prolyl 3-hydroxylase (EC 1.14.11.7) acting on procollagen, especially basement-membrane collagen IV. No contradictions. PN places it under collagen processing/folding; review core function is GO:0019797 procollagen-proline 3-dioxygenase activity in GO:0005788 ER lumen.
- **PN story / NEW pressure:** PN asserts the shared "collagen biosynthetic process" role. This is essentially already captured: GOA has GO:0032963 collagen metabolic process (the direct parent of GO:0032964; verified via OLS), accepted in the review. GO:0032964 is one step more specific and defensible (verified real, child of GO:0032963). Conclusion: low-pressure ADD of GO:0032964 (or rely on existing GO:0032963) — the substrate-specific story is captured; the projection is a justified mild refinement, not an over-reach.
- **Mapping strategy:** Correct. Group-level mapping with class/branch deliberately unmapped is sound (collagen processing group is substrate-coherent). GO:0032964 is narrower than P3H2's existing GO:0032963 and matches review BP framing; not broader (contrast TOMM20/HSPA8/RAB7A rejected-as-broader precedent). Catalytic gene, correctly handled.
- **Evidence alignment:** PN dossier carries no reference titles (mapping-only). Review evidence: IDA PMID:18487197 (collagen IV characterization), PMID:15063763 (ER/Golgi localization), plus KO/disease papers (PMID:29491144, 35499085). Substrate-specificity story (collagen IV) underpins the PN "collagen processing" placement; consistent.
- **Verdict:** Consistent and well-curated; PN collagen-biosynthesis story already captured (GO:0032963) with GO:0032964 a defensible narrower ADD.