## PIK3C3
- **UniProt:** Q8NEB9 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component` and `ALP|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component` ; **PN-node mapping:** type leaves `mapped / ok_for_propagation` to GO:0034271 (C-III type I) and GO:0034272 (C-III type II); group nodes `context_only / GO:0035032`; class `context_only / GO:0016236`. Both projected terms `already_in_goa_exact`.
- **Consistency:** Fully consistent. PN notes (VPS34 in PI3KC3-C1 making PI3P at nucleation; PI3KC3-C2 in endosome/autophagosome maturation + HOPS recruitment) match the review and deep research (falcon). Both projected complex terms are present: GO:0034271 ACCEPT (core, PI3KC3-C1) and GO:0034272 KEEP_AS_NON_CORE (PI3KC3-C2). The PN type-I = core / type-II = trafficking split mirrors the review's core-vs-non-core split exactly.
- **PN story / NEW pressure:** No new pressure — PN's complex memberships are already in GOA and the review. Both type-specific complex terms (GO:0034271/GO:0034272) verified real via the review's annotations; GO:0097352 autophagosome maturation (used in core_functions) verified real via OLS. The review additionally REMOVEs miscalls (GO:0004672 protein kinase, GO:0043491 PI3K/AKT) consistent with VPS34 being a class III lipid kinase. Conclusion: already captured; PN adds no over-reach.
- **Mapping strategy:** No change. The two `mapped` component leaves are correctly the only propagating nodes; the group/class nodes are correctly `context_only` (generic GO:0035032 / GO:0016236 not propagated). This is the model case for "only explicit complex-component leaves propagate to GO complex terms."
- **Evidence alignment:** PN cites PI3KC3-C1/C2 reviews + Matsunaga (ATG14L/Rubicon) Nat Cell Biol; review anchors the same complex biology to PMID:40442316 (PI3KC3-C1 structure), PMID:33637724, PMID:7628435 (substrate specificity). Substantive overlap on complex composition and PI3P output.
- **Verdict:** Fully consistent and well-scoped; PN complex projections already captured, type-I/type-II split correctly preserved. No edits required.