## PIP5K1B
- **UniProt:** O14986 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagic lysosome reformation|Regulation of autolysosome membrane composition` ; **PN-node mapping:** `group` = no_mapping (broad container); `class` (Autophagic lysosome reformation) = context_only, too_broad_to_propagate → GO:0007040 lysosome organization; `branch` = no_mapping. No GO projected.
- **Consistency:** Consistent. Notes, review, and PN agree the core MF is PI4P 5-kinase (GO:0016308 → PI(4,5)P2), and that the PN/ALR role rests on Rong et al. (PMID:22885770), not on the PN row alone. Review correctly treats PN node as too broad to be evidence.
- **PN story / NEW pressure:** PN asserts an ALR/autolysosome-membrane role absent from prior GO. Review adds GO:0007040 lysosome organization (action NEW, IMP, PMID:22885770) as the best available broad term, and proposes a genuinely novel "autophagic lysosome reformation" child term. OLS search confirms no existing GO term for autophagic lysosome reformation — so the proposed_new_term is warranted (candidate). Verdict: ADD broad GO:0007040 (done) + propose ALR term (done).
- **Mapping strategy:** This gene does not change the node mapping; the node correctly stays context_only and projects nothing. The review's GO:0007040 matches the PN node's context-GO exactly (not broader/narrower) but is sourced from the primary ALR paper rather than node propagation — methodologically sound.
- **Evidence alignment:** Minimal PN overlap. PN cites one review ("Membrane Trafficking in Autophagy"); review anchors on primary PMID:22885770 (Rong et al.) plus PMID:8955136 (PIP5KIbeta identity) and Reactome. The url: ref to nature.com/ncb2557 duplicates PMID:22885770.
- **Verdict:** Consistent; PN ALR story correctly drives a NEW broad lysosome-organization annotation and a justified proposed ALR term (no existing GO equivalent). No edits required. Minor: url:nature.com/ncb2557 reference duplicates PMID:22885770.