## RAB24
- **UniProt:** Q969Q5 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagosome closure maturation and lysosome fusion|Specific function in autophagosome maturation and lysosome fusion unknown` ; **PN-node mapping:** `group` = no_mapping (unknown/residual category, no GO-mappable shared function); `class` = context_only, too_broad_to_propagate → GO:0016236 macroautophagy; `branch` = no_mapping. No GO projected.
- **Consistency:** Consistent. Notes, review, and PN agree RAB24 is an atypical, predominantly GTP-bound Rab acting in late/basal autophagic-compartment maturation/clearance (PMID:26325487), not in starvation-induced formation. PN explicitly flags the leaf as "function unknown" and no-mapping; review used it as context only. No contradictions.
- **PN story / NEW pressure:** None. PN makes no positive functional assertion (residual "unknown" node, no projected GO). Review independently MODIFYs generic GO:0006914 autophagy → GO:0097352 autophagosome maturation based on primary evidence — finer than anything PN asserts. Verdict: already captured / PN adds no pressure.
- **Mapping strategy:** This gene does not change the node. no_mapping is appropriate for a residual "unknown" category; the review's GO:0097352 is far narrower than the class-level context GO:0016236 and is correctly derived from the paper, not from node propagation. Good restraint — projecting macroautophagy here would over-annotate (TRAPP precedent).
- **Evidence alignment:** Minimal overlap. PN cites one review ("Membrane Trafficking in Autophagy"); review uses primary PMID:26325487, 10660536 (atypical Rab biochem), 16034420 (rabenosyn-5). Several generic protein-binding IPI rows (interactome papers) marked over-annotated; HTP mitochondrion and Reactome secretory-granule rows marked over-annotated — reasonable.
- **Verdict:** Consistent; PN "unknown/no-mapping" placement is honest and the review supplies the specific autophagosome-maturation call. No NEW pressure, mapping correct. No edits required.