## RETREG2
- **UniProt:** Q8NC44 (FAM134A) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (focused; ER-phagy receptor, RHD + LIR, collagen QC)
- **PN placement:** `Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy` ; **PN-node mapping:** type→mapped/ok_for_propagation_to_go GO:0061709 reticulophagy (ancestors group/class/branch all no_mapping containers).
- **Consistency:** Excellent. Deep-research notes, review YAML, PN annotation and PN-node mapping all agree RETREG2/FAM134A is an ER-anchored selective-autophagy (ER-phagy/reticulophagy) receptor: stress-activated, RHD shapes/curves ER, LIR binds ATG8 to deliver ER fragments to autophagosomes. PN's "ERphagy"→"reticulophagy synonym" rationale matches the review's `description`. No contradictions. Foundational refs shared (PMID:26040720, PMID:34338405).
- **PN story / NEW pressure:** PN projects GO:0061709 reticulophagy as new_to_goa. Verified real (OLS) and confirmed ABSENT from RETREG2 GOA (GOA carries GO:0140506 adaptor activity, GO:0061753 substrate-to-autophagosome, ER-membrane CC, but NOT the reticulophagy BP). The review captures the molecular function (GO:0140506 ER-autophagosome adaptor activity, ACCEPT/core) and the generic process (GO:0061753) but never asserts the specific BP reticulophagy. So GO:0061709 is a genuine, defensible **ADD** the review omits — and it is more specific/precise than the generic GO:0061753 already accepted. Conclude: ADD reticulophagy (verified real).
- **Mapping strategy:** Correct and conservative. Only the ERphagy leaf propagates (to a narrow, exactly-matching process term); the broad receptor/substrate-selection/branch ancestors are correctly no_mapping. Process-term projection here is narrower than (not broader than) the review's accepted MF/CC, so the TOMM20/HSPA8 "too broad" precedent does not apply. No node-status change warranted.
- **Evidence alignment:** Strong overlap. PN's single reference (FAM134 paralogues EMBO reports = PMID:34338405) is in the review (HIGH/VERIFIED). Review additionally anchors on the foundational FAM134 ER-phagy paper PMID:26040720.
- **Verdict:** Fully consistent; the reticulophagy BP is a justified ADD the review currently lacks (function captured at MF/generic-BP level only).
- **Recommended edits:** [YAML] add GO:0061709 reticulophagy (BP, involved_in; the specific process for this ER-phagy receptor) — currently absent; more precise than the accepted generic GO:0061753. Cite PMID:26040720/PMID:34338405.
- **2026-06-18 follow-up:** Implemented the YAML edit: added GO:0061709 reticulophagy as a NEW BP recommendation and added it to the core ER-phagy function while retaining GO:0061753 substrate localization to autophagosome.