## SEC11A
- **UniProt:** P67812 (SPC18) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|ER signal peptidase`; **PN-node mapping:** group mapped, ok_for_propagation_to_go, GO:0005787 (signal peptidase complex); class GO:0015031 (protein transport).
- **Consistency:** Strong agreement. Deep research, review YAML, and PN all identify SEC11A as the catalytic serine-endopeptidase subunit of the SPC-A paralog (Ser-56 triad, EC 3.4.21.89, membrane-thinning specificity). PN's "ER signal peptidase" node correctly captures complex membership. No contradictions.
- **PN story / NEW pressure:** PN asserts only complex membership (GO:0005787) and the broad transport class (GO:0015031). Both already captured: review has GO:0005787 (IDA/IPI/IBA/IEA) plus the catalytic MF (GO:0009003 signal peptidase activity, GO:0004252 serine-type endopeptidase activity, EXP/IDA) — the latter being the gene's distinguishing function, which the PN node (a CC-level membership) does NOT assert. So PN under-specifies SEC11A's catalytic MF rather than over-reaching. No NEW term needed. Conclude: already captured (review is richer than PN).
- **Mapping strategy:** Mapping is correct but blunt: the node maps the whole "ER signal peptidase" group to the CC GO:0005787, which conflates catalytic (SEC11A/C) and accessory (SPCS1/2/3) members. For SEC11A specifically the catalytic peptidase MF is the salient function and is not represented at the node. Node need not change (GO:0005787 is right for all four), but a node-level note should distinguish catalytic-subunit MF (GO:0009003/GO:0004252) for SEC11A/C. GO:0015031 protein transport is acceptably broad. No precedent-style over-reach.
- **Evidence alignment:** PN row carries no titles; review's catalytic evidence (PMID:34388369 cryo-EM/triad; Reactome signalase reactions; PMID:36454823 QC; PMID:28423309 cavinafungin) and falcon deep research (liaci2021) all converge on the catalytic identity. Congruent.
- **Verdict:** CONSISTENT; PN captures CC membership but omits the catalytic MF that defines SEC11A (already in review). No edit required.
- **Recommended edits:** [MAP] At the "ER signal peptidase" node, annotate that catalytic subunits SEC11A/SEC11C additionally project signal peptidase MF (GO:0009003 / GO:0004252), distinct from accessory subunits — so the node does not flatten catalytic vs accessory members.