## SEC11C
- **UniProt:** Q9BY50 (SPC21) · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|ER signal peptidase`; **PN-node mapping:** group mapped, ok_for_propagation_to_go, GO:0005787 (signal peptidase complex); class GO:0015031 (protein transport).
- **Consistency:** Strong agreement. Deep research, review YAML, and PN all identify SEC11C as the catalytic serine-endopeptidase subunit of the SPC-C paralog (Ser-68 triad, EC 3.4.21.89), the paralog of SEC11A. PN's "ER signal peptidase" node correctly captures complex membership. No contradictions.
- **PN story / NEW pressure:** Identical to SEC11A. PN asserts CC membership (GO:0005787) + broad transport (GO:0015031), both already in the review, which additionally carries the catalytic MF (GO:0009003/GO:0004252, EXP/IDA from PMID:34388369). PN under-specifies the catalytic MF rather than over-reaching. No NEW term. Conclude: already captured.
- **Mapping strategy:** Same as SEC11A: node maps the catalytic+accessory group to the CC GO:0005787, which is correct for membership but does not surface SEC11C's catalytic peptidase MF. Node need not change; a catalytic-vs-accessory distinction note belongs at the node. GO:0015031 acceptably broad; no over-reach.
- **Evidence alignment:** PN row carries no titles; review evidence (PMID:34388369 structure/triad; Reactome signalase reactions; PMID:36454823 QC redundancy with SEC11A; PMID:28423309 cavinafungin) and falcon deep research (liaci2021) converge on the catalytic identity. Note PMID:26446786 names SEC11A (not SEC11C) — review correctly downgraded its relevance to SEC11C to LOW (background only).
- **Verdict:** CONSISTENT; PN captures CC membership but omits catalytic MF (already in review). No edit required.
- **Recommended edits:** [MAP] Same node-level note as SEC11A: flag that catalytic subunits SEC11A/SEC11C project signal peptidase MF (GO:0009003 / GO:0004252) distinct from the non-catalytic SPCS subunits.