## SERPINH1
- **UniProt:** P50454 (HSP47) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding` ; **PN-node mapping:** mapped → GO:0032964 (collagen biosynthetic process, new_to_goa)
- **Consistency:** Strong. Review, notes and PN all describe HSP47 as an ER-resident, collagen-specific (non-inhibitory serpin) chaperone that binds the triple-helical procollagen region. Core MFs = collagen binding (GO:0005518) and protein folding chaperone (GO:0044183), in ER lumen/ERGIC. Review correctly MARKS_AS_OVER_ANNOTATED the inherited serpin protease-inhibitor activity. Fully consistent with the PN collagen-folding node.
- **PN story / NEW pressure:** PN asserts collagen biosynthetic process (GO:0032964, OLS-verified real, goa_status=new_to_goa — GOA confirms only GO:0030199 collagen fibril organization present, not GO:0032964). HSP47 is genuinely dedicated to collagen maturation (OI10 disease confirms essentiality), so a collagen-process BP is defensible. The review already has GO:0030199 (collagen fibril organization, KEEP_AS_NON_CORE) as its process annotation. GO:0032964 is a reasonable, slightly more upstream alternative/addition. Conclude: **ADD defensible but largely already captured** by GO:0030199 — marginal value.
- **Mapping strategy:** Single clean node; status=mapped scope=ok is appropriate. GO:0032964 is neither broader nor narrower than the review's GO:0030199 (sibling process emphasising biosynthesis vs extracellular fibril assembly); HSP47 acts upstream in the ER, so GO:0032964 arguably fits HSP47's ER role better than fibril organization. No mapping change needed.
- **Evidence alignment:** PN row carries no reference titles; review cites UniProt + collagen-chaperone literature. No conflict.
- **Verdict:** Consistent and high-quality. **Recommended edits:** optionally add GO:0032964 collagen biosynthetic process (KEEP_AS_NON_CORE) to align with PN, since it captures HSP47's ER-upstream role better than the existing GO:0030199 fibril-organization term [YAML]; otherwise no change.