## SH3GLB1
- **UniProt:** Q9Y371 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component` ; **PN-node mapping:** `type` leaf mapped, `ok_for_propagation_to_go` → GO:0034272, goa_status `more_specific_than_existing_goa`; ancestors GO:0035032 / GO:0016236 context_only.
- **Consistency:** Consistent. Notes, review, and PN agree SH3GLB1/Bif-1/endophilin B1 is a POSITIVE N-BAR/SH3 adaptor that activates PI3KC3 via UVRAG (PMID:17891140) and drives ATG9/Golgi membrane fission (PMID:21068542). PN Notes ("binds to UVRAG and promotes activity") correctly state the positive direction — contrast with the RUBCNL row, which was mislabeled. No contradictions.
- **PN story / NEW pressure:** PN asserts GO:0034272 membership. GOA has only generic GO:0032991 (protein-containing complex, IDA+IEA), so GO:0034272 is `more_specific_than_existing_goa`. Review handles this via MODIFY of GO:0032991 → proposed_replacement GO:0034272 (rather than a standalone NEW row). GO:0034272 verified real. Review also adds membrane-fission (GO:0090148) and positive regulation of membrane tubulation (GO:1903527) as core — both verified real, non-obsolete, and beyond the PN story. Verdict: ADD/refine to GO:0034272 (review does via MODIFY) — aligned with PN.
- **Mapping strategy:** Supports the C2-component mapping; the PN-projected GO:0034272 is NARROWER than the gene's existing generic GO:0032991, which is exactly the intended refinement (not an over-broad projection). As with the other C2 binders, `part_of` for an associating membrane-fission adaptor is defensible but borderline vs. an associated/recruitment relation — review flags this in suggested_questions. Ancestors correctly held too_broad.
- **Evidence alignment:** PN cites Annual Review, a cardiovascular review, and PMID:19270696. Review uses primary PMID:17891140 (Bif-1/UVRAG autophagy), 21068542 (ATG9/Golgi fission), 11604418 (endophilin membrane tubulation), 15452144/16227588 (mitochondria/Bax, non-core), 12456676 (LPAAT, non-core). PMID:19270696 is not cited in this review; the PN reference list is shared-branch boilerplate, only loosely SH3GLB1-specific.
- **Verdict:** Consistent; PN GO:0034272 refines the gene's generic GO:0032991 (more_specific) and the review captures it via MODIFY plus richer membrane-fission/tubulation MF/BP terms (all verified). No edits required.