## SIAH1
- **UniProt:** Q8IUQ4 · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (dual UPS + ALP placement)
- **PN placement:** UPS row `E3 ubiquitin and UBL ligases|RING|SIAH / SINA|SIA TRAF-like` and ALP row `Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway` ; **PN-node mapping:** UPS group `mapped`/ok_for_propagation = GO:0061630 ubiquitin protein ligase activity (already_in_goa_exact); ALP type `mapped`/ok_for_propagation = GO:0000423 mitophagy (flagged new_to_goa).
- **Consistency:** Review YAML, notes and PN UPS annotation are fully aligned on the catalytic RING E3 identity (GO:0061630 core; EC 2.3.2.27; zinc fingers; homodimer). The ALP/mitophagy PN row is the one divergence: the review contains NO autophagy/mitophagy annotation, GOA has none, and SIAH1-uniprot.txt mentions SNCA/SNCAIP ubiquitination but not mitophagy or PINK1. The deep-research notes likewise do not mention the PINK1-SIAH1-synphilin mitophagy pathway.
- **PN story / NEW pressure:** PN asserts a PRKN-independent PINK1-SIAH1-SNCAIP mitophagy role absent from existing GO. The supporting paper (Szargel et al. 2016 HMG, "PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway") is real and not in the publications cache or the review. GO:0000423 mitophagy is a verified real term (OLS). This is a defensible ADD candidate, but it rests on a single primary paper not yet read in full and not in cache — propose as a NEW annotation pending full-text verification, not a slam-dunk.
- **Mapping strategy:** This gene does not require changing either node's status. The UPS group mapping to GO:0061630 is exact and correct (catalytic ligase kept as core, per the SIAH1 KEY PATTERN). The ALP type→GO:0000423 propagation is reasonable IF the Szargel evidence is verified; scope ok_for_propagation is acceptable. The zinc ion binding IDA was ACCEPTed and the wrong citation already flagged correctly (see below) — no re-mapping needed.
- **Evidence alignment:** Strong overlap on the UPS side conceptually but NOT by PMID — the PN UPS row cites only "19489725 / rev" (a review), while the review's ligase support is PMID:9334332/19224863/28546513/33591310. The PN ALP row cites the Szargel HMG mitophagy paper + a tandfonline PRKN-independent-mitophagy review, neither of which appears in the review references. Divergence is total on the mitophagy evidence.
- **Verdict:** Catalytic E3 mapping consistent and correct; mitophagy is a genuine NEW-GO opportunity (GO:0000423, verified) currently missing from review and GOA. The PMID:11863358 zinc-binding citation is correctly flagged WRONG_IDENTIFIER in reference_review (APOBEC RNA-editing paper, zero SIAH1 mention); SIAH1 zinc binding itself is correct (PMID:16085652), so ACCEPT of the term is sound — no change to that call.
  **Recommended edits:** [YAML] Add a mitophagy annotation `GO:0000423` (NEW, qualifier involved_in) for the PINK1-SIAH1-SNCAIP PRKN-independent pathway, supported_by the Szargel et al. 2016 HMG paper — first fetch/verify the PMID (Szargel HMG 2016; cache currently lacks it) and add it to `references`; mark UNDECIDED→NEW only after full-text confirmation. [REF] Keep the existing PMID:11863358 WRONG_IDENTIFIER flag (no change); optionally re-anchor the zinc IDA's primary support note to PMID:16085652.