## SPG11

- **UniProt:** Q96JI7 (spatacsin) · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway → Autophagic lysosome reformation → "Specific function in autophagic lysosome reformation unknown"` (1 row, ALP) ; **PN-node mapping:** group=`no_mapping` (function explicitly "unknown"); class (ALR)=`context_only`/`too_broad_to_propagate`→GO:0007040 lysosome organization; branch=`no_mapping`. **No GO propagates to SPG11 from PN.**
- **Consistency:** Consistent. Notes, review YAML and PN all center on ALR/lysosomal membrane remodeling. Review correctly treats the PN row as search context (its own notes say "this row is search context unless backed by primary literature"). No contradictions; neuronal axonal/synaptic rows kept as non-core, matching the deep-research framing.
- **PN story / NEW pressure:** PN's "ALR" story IS captured in GOA-equivalent terms the review accepts/adds: GO:0007040 lysosome organization, GO:0097212 lysosomal membrane organization, GO:0097753 membrane bending (all verified real, used as core). The review additionally proposes two genuinely new terms — "autophagic lysosome reformation" (parent GO:0007040) and "lysosome membrane recycling" (parent GO:0097212) — as `proposed_new_terms`, which is the right altitude since no exact ALR GO term exists. Conclude: **already captured at the available altitude; ADD only as proposed_new_terms (not mintable now).**
- **Mapping strategy:** This gene does not change the node. The PN class-level GO:0007040 exactly matches the review's chosen core term, so node status (`no_mapping` leaf, `context_only` class) is appropriate; no broader/narrower conflict.
- **Evidence alignment:** Strong overlap. PN cites the JCI ALR paper = review's PMID:25365221 (ACCEPT, core). Review adds extensive endolysosomal evidence (PMID:40175557 structure, 29949766, 37871017, 23825025) PN does not list — divergence is enrichment, not conflict.
- **Verdict:** Fully consistent, well-curated. No edits needed.