## SPNS1

- **UniProt:** Q9H2V7 (Spinster homolog 1) · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway → Autophagic lysosome reformation → Efflux of autophagy products` (1 row, ALP) ; **PN-node mapping:** leaf group=`mapped`/`ok_for_propagation_to_go`→GO:0007041 lysosomal transport; class (ALR)=`context_only`/`too_broad`→GO:0007040; branch=`no_mapping`. **Projects GO:0007041 (new_to_goa).**
- **Consistency:** Consistent. Notes, review YAML and PN agree SPNS1 is a lysosomal proton-driven lysophospholipid (LPC/LPE) efflux transporter, and that "efflux of autophagy products" is biologically plausible. The review explicitly accepts the PN GO:0007041 projection as a `NEW` annotation and cites the PN mapping file. No contradictions.
- **PN story / NEW pressure:** PN asserts a lysosomal-export role not previously in GOA. GO:0007041 lysosomal transport is **verified real** (OLS: "movement into/out of/within a lysosome") and is genuinely absent from SPNS1 GOA (confirmed in goa.tsv) — the review correctly adds it as `NEW`. The review goes further with two `proposed_new_terms` (lysophospholipid:proton symporter activity; lysosomal lysophospholipid export), the right altitude for the precise cargo/direction the broad GO:0007041 misses. Conclude: **ADD GO:0007041 (done as NEW) + proposed_new_terms; defensible.**
- **Mapping strategy:** Gene does not change the node; GO:0007041 is appropriately broad (an over-broad "lysosomal transport" is acceptable here as the only fitting current term, and the review flags it as broad). Status/scope correct.
- **Evidence alignment:** Partial overlap. PN cites the Spinster ALR/mTOR PNAS paper and a trafficking review (titles only). Review's core evidence is the direct human/mouse transporter literature (PMID:36161949, 37075117, 39739806, 40608416) — stronger, mechanism-level; the PN ALR/mTOR paper is not in review `supported_by` but is consistent.
- **Verdict:** Fully consistent; PN projection correctly actioned as NEW. No edits needed.