## SQSTM1
- **UniProt:** Q13501 (p62/sequestosome-1) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (very large, ~3380 lines; ~70 IPI bare-protein-binding entries kept non-core)
- **PN placement:** ALP `Autophagy substrate selection|Selective autophagy receptor|{Mitophagy,Pexophagy,Xenophagy,Aggrephagy,Midbody autophagy}` + `Autophagophore...|component recruitment` + UPS `Proteasome...|adaptors|PB1|UBA` and `Ubiquitin and UBL binding|trafficking|selective autophagy|UBA` ; **PN-node mapping:** leaf types mapped → GO:0000423 mitophagy, GO:0000425 pexophagy, GO:0098792 xenophagy, GO:0035973 aggrephagy, GO:0160247 cargo adaptor (midbody); UPS adaptors group → GO:0070628 proteasome binding; all ancestors no_mapping/context_only.
- **Consistency:** Strong agreement on the core selective-autophagy-receptor story across deep research, review, PN notes, and node mappings. Review ACCEPTs aggrephagy (GO:0035973), mitophagy (KEEP_AS_NON_CORE — recruitment but dispensable for clearance, PMID:20890124), pexophagy (GO:0000425, IDA PMID:26344566). No contradictions; PN notes (PEX5-ATM, TRAF6/ALFY midbody, bacteria) match review description.
- **PN story / NEW pressure:** PN surfaces three terms absent from GOA/review: GO:0098792 xenophagy (verified real; GOA has none — review only narrates antibacterial autophagy in `description`), GO:0160247 autophagy cargo adaptor activity (verified; review uses GO:0030674 protein-macromolecule adaptor + GO:0140036 reader instead), and GO:0070628 proteasome binding (verified; PB1/UBA shuttle role). Cargo-adaptor and xenophagy are defensible ADDs (the recurring receptor-MF elevation pattern); proteasome binding is plausible but weaker (PB1/UBA shuttle to proteasome is real but secondary).
- **Mapping strategy:** Mappings are sound and conservative (ancestors held back). The KEY PATTERN applies: elevate GO:0160247 cargo adaptor over bare protein binding. Review already captures this via GO:0030674; harmonizing to GO:0160247 would align review with PN.
- **Evidence alignment:** Strong overlap on ALP rows (Pankiv 17580304, Pilli/Wild xenophagy, ATM-pexophagy 26344566, TRAF6 midbody). PN UPS row 7 cites bare PMID 15340068 (proteasome-shuttle) not in review references.
- **Verdict:** CONSISTENT; defensible ADD of GO:0160247 cargo adaptor activity and GO:0098792 xenophagy to the review.