## SRP68
- **UniProt:** Q9UHB9 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Protein transport|Signal recognition particle component` ; **PN-node mapping:** group=mapped scope=ok_for_propagation_to_go→GO:0006614 (SRP-dependent cotranslational protein targeting to membrane); class `Protein transport`=mapped→GO:0015031; branch=no_mapping.
- **Consistency:** Strong and mutually consistent. Deep research, review YAML, and PN annotation all describe SRP68 as the 68 kDa S-domain SRP subunit that binds/remodels 7SL RNA (opening the 5f loop) and heterodimerizes with SRP72. The PN "SRP component" label and GO:0006614 mapping match the review's core BP (GO:0006614 IBA/IEA, ACCEPT). No contradictions.
- **PN story / NEW pressure:** PN asserts only the canonical SRP cotranslational-targeting role, already captured (GO:0006614, GO:0008312 7S RNA binding, GO:0005047 SRP binding, GO:0005786 SRP membership). The disease link (SCN10, PMID:32273475) and nucleolar assembly pool are in the review but outside the PN story. Conclusion: **already captured** (no NEW pressure).
- **Mapping strategy:** No change needed. GO:0006614 (goa_status already_in_goa_exact) is present and ACCEPTed — exact projection, not broader than the review. The class-level GO:0015031 is a broad class target, not asserted of SRP68. Note the review independently flags GO:0030942 (ER signal-sequence receptor activity, IEA) as over-annotated — that activity belongs to SRPR/SRPRB, not the SRP S-domain scaffold; internal QC unrelated to the PN node.
- **Evidence alignment:** PN dossier lists no reference titles; alignment via projected-term provenance. Review's core support (PMID:24700861 SRP68-RBD RNA remodeling; PMID:27899666 SRP68/72 S-domain structures; PMID:16672232 RNA/SRP72 binding domains; PMID:34208095 SRP review) all encode the SRP cotranslational-targeting biology the PN maps to. No divergence.
- **Verdict:** Fully consistent; PN already captured, review more granular (adds 7S RNA binding, SRP binding, ribosome binding). No edits warranted.