## STUB1
- **UniProt:** Q9UNE7 (CHIP) · **batch:** proteostasis-batch-2026-06-07b · **review status:** COMPLETE (197 annotations reviewed)
- **PN placement:** spans 5 rows across CY/ALP/UPS — `Cytonuclear|Chaperone|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase`; `ALP|...|CASA complex component`; `ALP|CMA|Effectors|Substrate selection`; `UPS|E3 ligases|RING variant|UBOX|TPR`; `UPS|...|STUB1/CHIC2 complex` ; **PN-node mapping:** mapped → GO:0061630 (Ub ligase activity), GO:0031072 (HSP binding), GO:0035973 (aggrephagy, new), GO:0061684 (CMA), GO:0061740 (CMA targeting), GO:0000151 (Ub ligase complex)
- **Consistency:** Strong. Review, notes and PN agree on the dual identity — genuine U-box E3 ligase (GO:0061630 ACCEPT, core) AND HSP70/HSP90 co-chaperone (TPR; GO:0030544/0051879/0031072/0051087 ACCEPT). Review explicitly distinguishes both MFs as the prompt requires. CMA (GO:0061684) and Ub-ligase-complex (GO:0000151) present in review, matching two PN projections. No contradictions.
- **PN story / NEW pressure:** PN row 2 asserts CASA/aggrephagy (GO:0035973, verified real, goa_status=new_to_goa). This is NOT in the review (no aggrephagy/CASA/BAG3/HSPB8 annotation anywhere). Review covers mitophagy + CMA as non-core but omits aggrephagy. STUB1 is a bona fide CASA component (BAG3-HSPB8-HSPA8-STUB1) → **ADD is defensible** (aggrephagy, IBA/IC, non-core). proposed_new_terms is empty.
- **Mapping strategy:** Node mappings are sound and conservative (E3-complex node → GO:0000151 membership not catalytic activity; CMA class held context_only). No change needed; aggrephagy is the only genuinely novel projection.
- **Evidence alignment:** PN cites CASA review (tandfonline), CMA review (Nat Rev MCB), PMID:12646216, PMID:40796662 (STUB1/CHIC2). Review is UniProt/GOA-driven (197 IPI/IBA/IEA refs); none of the four PN-specific titles appear in the review. Divergence is in the autophagy-receptor literature.
- **Verdict:** Consistent and high-quality; one warranted addition (aggrephagy). **Recommended edits:** add GO:0035973 aggrephagy as KEEP_AS_NON_CORE supported by CASA literature [YAML]; optionally cite PMID:40796662 / CASA review in references [REF].