## TANK
- **UniProt:** Q92844 (I-TRAF) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (~1282 lines; ~25 IPI bare-protein-binding non-core)
- **PN placement:** ALP `Autophagy substrate selection|Autophagy receptor regulation|Mitophagy` + UPS `Ubiquitin and UBL binding|DUB cofactor|USP10|UBZ1-type ZnF` ; **PN-node mapping:** Receptor-regulation/Mitophagy→GO:0000423 (new_to_goa); UPS DUB-cofactor ancestors no_mapping (class context_only GO:0140036).
- **Consistency:** Major divergence. The review and TANK-notes contain NO autophagy/mitophagy content at all — TANK is treated purely as (1) the non-catalytic adaptor/scaffold of the TBK1-IKKepsilon-TANK complex driving type I IFN (GO:0060090 molecular adaptor, ACCEPT; GO:0032481 positive regulation of type I IFN production), (2) a scaffold that activates USP10-dependent deubiquitination of TRAF6/NEMO to restrain NF-kB (GO:0035800 deubiquitinase activator activity), and (3) a TRAF1/2/3 binder. The PN's mitophagy story ("TANK-TBK1 complex phosphorylates OPTN in mitophagy") rests on a single PNAS paper (Richter/Heo 2016) and is absent from the review.
- **PN story / NEW pressure:** PN asserts a role (GO:0000423 mitophagy, new_to_goa) NOT in GOA and NOT in the review. This is an over-reach. TANK is the **regulatory/scaffold subunit** that bridges TBK1 — it does not itself perform mitophagy. The connection is indirect (TANK→TBK1→OPTN-P→mitophagy). At most this warrants a regulation term, and even that is thin: the PNAS paper foregrounds TBK1/OPTN, with TANK as part of the kinase complex. Bare GO:0000423 mitophagy involved_in is not defensible for TANK on current evidence; treat as candidate/context, not ADD.
- **Mapping strategy:** This gene does NOT justify the node's mitophagy mapping for TANK. The PN node "Autophagy receptor regulation" projecting bare GO:0000423 (a process, not a regulation term) is the same scope drift seen for TBK1, but weaker here because TANK is one step further removed (regulatory adaptor of the kinase). KEY PATTERN: TANK is the regulatory adaptor (per the brief), not a receptor — cargo-adaptor MF does not apply; its MF is GO:0060090 molecular adaptor (already core).
- **Evidence alignment:** No overlap on the autophagy axis — PN's sole mitophagy ref (Richter/Heo PNAS) is not in the TANK review (the review's TBK1 interactions are IFN/NF-kB-context IPIs). The shared PNAS paper IS used in OPTN and TBK1 reviews, not TANK.
- **Verdict:** OVER-REACH — PN projects GO:0000423 mitophagy (new_to_goa) onto TANK with no support in review/notes; TANK is an indirect regulatory scaffold of TBK1. **Recommended edits:** [MAP] drop/demote TANK's "Autophagy receptor regulation|Mitophagy"→GO:0000423 projection (indirect, single-paper, regulatory-subunit role) — at most a regulation-of-mitophagy context, not a direct mitophagy annotation; do not add to the review without TANK-specific evidence.