## TBK1
- **UniProt:** Q9UHD2 (TANK-binding kinase 1) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (~3069 lines; ~55 IPI bare-protein-binding non-core)
- **PN placement:** ALP `Pre-initiation autophagy signaling|mTORC1 pathway, direct|Modulator of mTORC1 activity` + `Autophagy substrate selection|Autophagy receptor regulation|Mitophagy` + UPS `Ubiquitin and UBL proteins|UBL domain|other enzymes|kinase` ; **PN-node mapping:** Receptor-regulation/Mitophagy→GO:0000423 (more_specific_than_existing_goa); mTORC1-modulator type no_mapping (class context_only GO:0010506 regulation of autophagy); UBL-domain ancestors context_only; ancestors no_mapping.
- **Consistency:** TBK1 is correctly framed in PN notes and review as the **catalytic kinase** that phosphorylates receptors (OPTN-Ser177, p62, NDP52, TAX1BP1), not as a receptor itself. Review/notes (Wild 2011, Richter/Heo 2016 PMID:27035970) match. The PN dossier itself flags the mTORC1-modulator and UBL-domain-kinase nodes as no_mapping/context (no over-propagation) — internally consistent.
- **PN story / NEW pressure:** PN's lone projected term is GO:0000423 mitophagy (process), marked more_specific_than_existing_goa. This is a mismatch with how TBK1 actually acts: TBK1 **regulates** mitophagy by phosphorylating receptors. GOA and the review correctly use regulatory terms — GO:0016239 positive regulation of macroautophagy (ACCEPT), GO:1904417 positive regulation of xenophagy, GO:0010508 positive regulation of autophagy. Annotating bare GO:0000423 mitophagy (involved_in) to the kinase risks the same over-reach the project warns against; positive-regulation-of-mitophagy framing is more defensible.
- **Mapping strategy:** PN node is "Autophagy receptor regulation" yet the projected GO term is the bare process GO:0000423, not a regulation term — internal scope drift. The narrower/regulatory review terms are preferable (TOMM20 precedent: prefer the more accurate term over the broader projected process). KEY PATTERN: TBK1 = kinase, so cargo-adaptor MF does not apply; core MF is GO:0004674 Ser/Thr kinase (ACCEPT).
- **Evidence alignment:** Strong overlap (SMCR8 review, TBK1-autophagy review, Richter 2016 PNAS mitophagy, PINK1 receptor recruitment). Same papers underlie review's positive-regulation terms.
- **Verdict:** CONSISTENT on biology; PN's bare GO:0000423 mitophagy projection is scope drift for a regulator — review's positive-regulation terms are better. **Recommended edits:** [MAP] for TBK1 the "Autophagy receptor regulation|Mitophagy" node should project a regulation term (GO:1901526 positive regulation of mitophagy, verified real) rather than the bare process GO:0000423; do not add GO:0000423 involved_in to the kinase review.