## TRAPPC11

- **UniProt:** Q7Z392 (C4orf41/Gryzun) · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway → Autophagophore initiation and elongation → Autophagy component recruitment to autophagophore → TRAPP complex component` (1 row, ALP) ; **PN-node mapping:** leaf type=`mapped`/`ok_for_propagation`→GO:0030008 TRAPP complex; group=`no_mapping`; class=`context_only`/`too_broad`→GO:0016236 macroautophagy; branch=`no_mapping`. **Projects GO:0030008 (already_in_goa_exact).**
- **Consistency:** Consistent, with the review going beyond PN. Falcon deep research (the only one of the six that completed) plus notes and YAML agree on TRAPPIII membership + early-secretory ER/ERGIC/Golgi traffic + TRAPP-stability, AND add a direct autophagy role from PMID:31575891 (patient fibroblasts fail autophagic flux / fail to seal isolation membranes). No contradictions; the review supplements the PN complex-only mapping with a gene-specific autophagy BP.
- **PN story / NEW pressure:** PN restricts to GO:0030008 membership, but TRAPPC11 has direct human autophagy evidence the PN node does not project. Review adds GO:0097352 autophagosome maturation as `NEW` (verified real via OLS; absent from GOA, confirmed). **Caveat (verified):** GO:0097352's definition is "removal of PI3P/Atg8-LC3 after phagophore closure" (a disassembly step), whereas PMID:31575891 describes a failure to *seal/close* isolation membranes — which maps more naturally to GO:0000045 autophagosome assembly. The NEW term direction is defensible but slightly off the cited mechanism. Conclude: **ADD an autophagy BP (defensible), but reconsider GO:0097352 vs GO:0000045 for the sealing/closure phenotype.**
- **Mapping strategy:** Gene does not change the TRAPP node (GO:0030008 correct). The autophagy addition is gene-specific and correctly NOT propagated from the shared TRAPP bucket.
- **Evidence alignment:** Overlap on TRAPP: PN cites PMID:27066478 + Frontiers review = review core. Review enriches with PMID:21525244 (TRAPP identification), 19942856 (Golgi-exit screen), 27862579 (CDG), and 31575891 (autophagy, PN does not list).
- **Verdict:** Consistent; one substantive curation question. **Recommended edits:** in TRAPPC11-ai-review.yaml, reconsider the `NEW` GO:0097352 autophagosome maturation against GO:0000045 autophagosome assembly, since PMID:31575891 evidence concerns isolation-membrane sealing/closure, not the post-closure PI3P/LC3-removal step GO:0097352 defines.