## TRAPPC12

- **UniProt:** Q8WVT3 (TRAMM/TTC-15) · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway → Autophagophore initiation and elongation → Autophagy component recruitment to autophagophore → TRAPP complex component` (1 row, ALP) ; **PN-node mapping:** leaf type=`mapped`/`ok_for_propagation`→GO:0030008 TRAPP complex; group=`no_mapping`; class=`context_only`/`too_broad`→GO:0016236 macroautophagy; branch=`no_mapping`. **Projects GO:0030008 (already_in_goa_exact).**
- **Consistency:** Consistent. Notes and YAML agree on two directly-supported tracks — interphase TRAPP/TRAPPIII early-secretory traffic, and a moonlighting mitotic kinetochore/CENP-E role (PMID:25918224) — and explicitly **decline** a TRAPPC12-specific autophagy annotation ("I am not adding a direct autophagy annotation… autophagy is represented by TRAPPIII/RAB1 context only"). This matches the PN complex-only mapping. No contradictions.
- **PN story / NEW pressure:** PN restricts to GO:0030008 membership; unlike TRAPPC11, TRAPPC12 has **no** direct gene-specific autophagy evidence, so the review correctly does not mint an autophagy BP (`proposed_new_terms: []`). GO:0030008 is verified real and already in GOA. The mitotic moonlighting functions (GO:0051310, GO:0090234, GO:1905342) are outside the PN scope and correctly flagged as non-PN-propagation targets. Conclude: **already captured; no NEW warranted — good asymmetry vs TRAPPC11.**
- **Mapping strategy:** Gene does not change the node (GO:0030008 correct, macroautophagy correctly held at `context_only`). The mitotic functions are appropriately excluded from the shared TRAPP bucket.
- **Evidence alignment:** Overlap on TRAPP: PN cites PMID:27066478 + Frontiers review = review core. Review enriches with PMID:21525244 (TRAPP ID), 28777934 (CDG/encephalopathy), 25918224 (mitosis) — none in PN, all consistent. (Notes flag a spurious PANTHER PTHR21581 "D-Ala-D-Ala carboxypeptidase" artifact, correctly not used.)
- **Verdict:** Fully consistent; correctly conservative on autophagy. No edits needed.