## TRAPPC8
- **UniProt:** Q9Y2L5 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component` ; **PN-node mapping:** type-leaf mapped, scope=ok_for_propagation_to_go, GO:0030008 TRAPP complex (already_in_goa_exact)
- **Consistency:** Coherent and the strongest autophagy case. Notes, review, PN row ("TRAPP III, specific subunit"), and node mapping agree TRAPPC8 (Trs85 ortholog) is the TRAPPIII-specific subunit driving ATG9 cycling for autophagy initiation. Review adds GO:0006914 autophagy as **action: NEW** (IMP, PMID:26711178), modifies collagen biosynthetic process (GO:0032964) and COPII coat assembly to ER-to-Golgi transport, keeps Golgi organization non-core. No contradictions.
- **PN story / NEW pressure:** PN asserts ATG9/ATG2 trafficking + TRAPPIII autophagy — and unlike the core subunits this is directly supported for TRAPPC8 (PMID:26711178 "maintaining the cycling pool of ATG9 required for initiation of autophagy"; "first to clearly characterise a role for mammalian TRAPP, in particular TRAPPC8, in bulk macroautophagy"). The review's NEW GO:0006914 autophagy is fully defensible. Conclusion: ADD (already proposed as NEW in the review).
- **Mapping strategy:** No change to node. Projected GO:0030008 (OLS-verified) already in GOA; review also carries TRAPPIII (GO:1990072, whose OLS definition notes autophagy regulation). The PN component-bucket scope is narrower than the gene's NEW autophagy annotation — correctly leaving autophagy at the gene level rather than projecting it from the bucket.
- **Evidence alignment:** Best overlap of the set: PN row uniquely lists PMID:26711178 (TBC1D14/TRAPP/ATG9), which the review uses as the load-bearing NEW-autophagy citation. Plus PMID:21525244, PMID:32095531 (TMEM131/collagen), PMID:27066478. No miscitation.
- **Verdict:** Consistent; ACCEPT mapping + endorse NEW autophagy (GO:0006914). Strongest PN-story-to-evidence match in the TRAPP set.
- **Recommended edits:** Optionally make the NEW term more specific to the autophagophore-recruitment leaf (e.g. GO:0000045 autophagosome assembly, OLS-verified) if ATG9-cycling/initiation evidence is judged to support assembly rather than only broad autophagy; otherwise GO:0006914 stands.