## TRIM17
- **UniProt:** Q9Y577 (terf/RNF16) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE
- **PN placement:** 2 rows — `ALP|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy`; `UPS|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY`. **PN-node mapping:** Midbody-autophagy type → mapped/ok GO:0160247 autophagy cargo adaptor activity (more_specific_than_existing_goa); RING group → mapped/ok GO:0061630 ubiquitin protein ligase activity (already_in_goa_exact); E3-ligase ancestors = no_mapping/context_only.
- **Consistency:** Consistent. PN (selective-autophagy receptor for midbodies + genuine RING E3), review and notes agree: TRIM17 has a real RING-HC domain, autoubiquitinates (PMID:19358823), degrades MCL1 to drive neuronal apoptosis, and acts in **target-selective** autophagy — broadly INHIBITING autophagic degradation while contributing to midbody autophagy via MCL1/BECN1 scaffolding (PMID:27562068). Functional RING → catalytic ligase MF correct. No contradictions; the nuance that TRIM17 is mostly an autophagy *inhibitor* is captured in both.
- **PN story / NEW pressure:** PN routes midbody autophagy through the cargo-adaptor MF GO:0160247 (verified real) because GO has NO dedicated "midbody autophagy" process term (confirmed — searchClasses returns nothing). The review already captures this MF as GO:0030674 protein-macromolecule adaptor activity (ACCEPT, IPI PMID:25127057) and GO:0006914 autophagy (ACCEPT) — so the role IS in GOA at the generic level, and GO:0160247 is the more specific upgrade (hence PN's "more_specific_than_existing_goa"). Defensible refinement, not a brand-new role. No new GO process term mintable for midbody autophagy.
- **Mapping strategy:** No node change needed. Cargo-adaptor MF over bare protein binding is the prescribed pattern and matches the review. Genuine RING → GO:0061630 already_in_goa_exact, correctly retained. Caution: TRIM17's autophagy role is predominantly inhibitory/selective; the cargo-adaptor MF should be scoped to the midbody-autophagy contribution, not read as a general pro-autophagy receptor.
- **Evidence alignment:** Strong overlap. PN cites the LIR/cargo-receptor review and the midbody paper (= PMID:27562068, review HIGH) and 33791238/19489725 (TRIM/E3 reviews). Review refs (PMID:27562068, 25127057, 19358823) cover the autophagy + ligase arms; the MCL1/neuronal-apoptosis primary paper (PMID:22023800, in notes) is not a cited reference in the review.
- **Verdict:** Consistent; cargo-adaptor MF upgrade warranted; RING ligase already captured. **Recommended edits:** [YAML] upgrade the GO:0030674 adaptor MF to the more specific GO:0160247 autophagy cargo adaptor activity (supported by PMID:27562068/25127057), scoped to midbody autophagy. [REF] consider adding PMID:22023800 (MCL1/ZWINT, neuronal apoptosis) to references to support the core MCL1-degradation function.
- **2026-06-18 follow-up:** Implemented the scoped YAML recommendation by adding GO:0160247 as a NEW midbody-selective autophagy cargo-adaptor recommendation, but retained GO:0030674 as the core MF after review feedback because TRIM17's dominant autophagy role is inhibitory/context-dependent. PMID:22023800 was added as a medium-relevance ZWINT/proliferation reference with an explicit caveat that the cached abstract does not support the MCL1 apoptosis claim.