## TXNDC16
- **UniProt:** Q9P2K2 · **batch:** proteostasis-batch-2026-06-11 · **review status:** COMPLETE (thorough; ER-luminal PDI-family glycoprotein, ERFAD/FOXRED2 partner)
- **PN placement:** 1 row — `ER proteostasis|Folding enzyme|Protein disulfide isomerases`. **PN-node mapping:** group→mapped GO:0003756 protein disulfide isomerase activity (ok_for_propagation_to_go, new_to_goa); class (Folding enzyme) and branch (ER proteostasis) no_mapping. Projected: GO:0003756 (new_to_goa).
- **Consistency:** CONTRADICTION. The review and notes (and deep research) explicitly conclude TXNDC16/ERp90 is a **non-catalytic** PDI-family member: none of its ~five Trx-like domains carry a canonical CXXC redox motif (PMID:21359175; review PMID:32971745 corroborates non-canonical CX8C/CX9C/CX6C motifs). The review asserts no catalytic oxidoreductase MF, leaves `proposed_new_terms: []`, and frames the best-supported role as an ERFAD/FOXRED2 ERAD-substrate-recruitment partner. The PN projects GO:0003756 protein disulfide isomerase activity (verified real via OLS) onto this gene by virtue of family membership — directly at odds with the gene-level finding of redox inactivity.
- **PN story / NEW pressure:** PN asserts PDI activity NOT in GOA (GOA has only GO:0005515 + localizations). But this is an OVER-REACH: catalytic PDI activity is contradicted by the absence of a CXXC active site. No defensible catalytic NEW term; an ERAD substrate-recruitment/adapter MF is plausible but unproven (review keeps it a suggested question). Conclude: PN PDI-activity projection over-reaches for THIS gene.
- **Mapping strategy:** The group→GO:0003756 mapping is reasonable for the *canonical catalytic* PDIs but should NOT propagate to TXNDC16, a redox-inactive family member (analogous to ERp27/ERp29 b-type pseudo-PDIs). This is a member-level exclusion, not a node-status change: the group mapping rationale already says "catalytically active family members," so TXNDC16 falls outside that scope.
- **Evidence alignment:** PN row carries no reference titles. Review evidence (PMID:21359175 HIGH/VERIFIED defining paper; PMID:25122923, 32971745, 19199708, 38673779) is far richer and all point to non-catalytic status. No shared citations to compare; no divergence beyond the PN's family-level inference lacking gene-specific support.
- **Verdict:** Inconsistent on the one substantive point — PN projects PDI catalytic activity that the review/literature refute (no CXXC). Review is correct; PN projection over-reaches.
- **Recommended edits:** [MAP] Exclude TXNDC16 (Q9P2K2) from the GO:0003756 protein disulfide isomerase activity projection (redox-inactive PDI-family member, no CXXC) — flag as member-level exception under the "Protein disulfide isomerases" group, do NOT project to GOA. [YAML] none required (review correctly omits a catalytic MF).